Safety Assessment of Hydrolyzed Wheat Protein and Hydrolyzed Wheat Gluten as Used in Cosmetics

International Journal of Toxicology
Christina L BurnettBart Heldreth

Abstract

The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) reviewed the product use, formulation, and safety data on hydrolyzed wheat protein and hydrolyzed wheat gluten, which function as skin- and hair-conditioning agents. The Panel determined that data from clinical and laboratory studies were sufficient to demonstrate that these ingredients will not elicit type 1 immediate hypersensitivity reactions in sensitized individuals and will not induce sensitization when the polypeptide lengths of the hydrolysates do not exceed 30 amino acids. The Panel concluded that hydrolyzed wheat gluten and hydrolyzed wheat protein are safe for use in cosmetics when formulated to restrict peptides to an average molecular weight of 3,500 Da or less.

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Citations

Dec 17, 2019·International Journal of Toxicology·Lillian C BeckerBart Heldreth
Apr 6, 2020·Contact Dermatitis·Maria A Bruusgaard-MouritsenLene H Garvey
Jun 28, 2019·Frontiers in Plant Science·Fabio AponeMaria Gabriella Colucci
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anca Maria JuncanFelicia Loghin
Aug 30, 2021·Comprehensive Reviews in Food Science and Food Safety·Haoran GaoVenu Gangur

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Methods Mentioned

BETA
electrophoresis
deamidation

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