Safety assessment of inhaled xylitol in mice and healthy volunteers

Respiratory Research
Lakshmi DurairajJoseph Zabner

Abstract

Xylitol is a 5-carbon sugar that can lower the airway surface salt concentration, thus enhancing innate immunity. We tested the safety and tolerability of aerosolized iso-osmotic xylitol in mice and human volunteers. This was a prospective cohort study of C57Bl/6 mice in an animal laboratory and healthy human volunteers at the clinical research center of a university hospital. Mice underwent a baseline methacholine challenge, exposure to either aerosolized saline or xylitol (5% solution) for 150 minutes and then a follow-up methacholine challenge. The saline and xylitol exposures were repeated after eosinophilic airway inflammation was induced by sensitization and inhalational challenge to ovalbumin. Normal human volunteers underwent exposures to aerosolized saline (10 ml) and xylitol, with spirometry performed at baseline and after inhalation of 1, 5, and 10 ml. Serum osmolarity and electrolytes were measured at baseline and after the last exposure. A respiratory symptom questionnaire was administered at baseline, after the last exposure, and five days after exposure. In another group of normal volunteers, bronchoalveolar lavage (BAL) was done 20 minutes and 3 hours after aerosolized xylitol exposure for levels of inflammatory...Continue Reading

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Citations

Mar 8, 2012·Journal of Aerosol Medicine and Pulmonary Drug Delivery·John Gar Yan ChanPhilip Chi Lip Kwok
Feb 18, 2006·Respiratory Research·Lakshmi DurairajJoseph Zabner
Jul 8, 2014·The Journal of Laryngology and Otology·Ö SakallioğluC Cingi
May 9, 2012·Inhalation Toxicology·Matthew D ReedLakshmi Durairaj
Apr 10, 2017·American Journal of Otolaryngology·Lin LinGuangbin Sun
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Methods Mentioned

BETA
lavage
Bronchoalveolar lavage
enzyme linked immunosorbent assays
ELISA

Software Mentioned

Flexivent system
SAS
Flexivent
Buxco

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