Safety Assessment of the Auto Manipulation Device for Acupuncture in Sprague-Dawley Rats: Preclinical Evaluation of the Prototype

Evidence-based Complementary and Alternative Medicine : ECAM
Geng-Hao LiuTzung-Yan Lee

Abstract

The Auto Manipulation Device for Acupuncture (AMDA) is designed for providing stable, quantified effects and higher frequency when doing lifting and thrusting manipulation. The purpose of this study is to investigate the safety of manipulation by AMDA in different frequency and duration in healthy rats. The study was divided into two parts: single intervention and once a day for a week. 12 rats and 15 rats were randomly allocated to different groups: Control (needle insertion only), AMDA (2Hz/10Mins), AMDA (2Hz/20Mins), AMDA (20Hz/10Mins), and AMDA (20Hz/20Mins) for single and repeated interventions. Real-time physiological functions, laboratory data, and the bilateral muscle tissue of acupoint (ST 36) were obtained after the intervention. We found neither real-time physiological functions nor laboratory data differences between control group and AMDA groups in both parts. In the muscle tissue samples, the slight damage had been observed in the AMDA group with a frequency of 2 Hz for 20 minutes after once intervention, and the repeated session groups noted more obvious tissue damage with fibrotic change. Although the period was shorter, higher frequency manipulation caused more damage that fibroblast nuclei became more slender ...Continue Reading

References

Oct 20, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·H M LangevinM J Cipolla
May 4, 2002·Nature Reviews. Molecular Cell Biology·James J TomasekRobert A Brown
Oct 22, 2004·American Journal of Physiology. Cell Physiology·Helene M LangevinAlan K Howe
Nov 20, 2004·Ultrasound in Medicine & Biology·Helene M LangevinBrian S Garra
Dec 16, 2006·World Journal of Gastroenterology : WJG·Yu-Qing LiYan-Hua Li
May 8, 2007·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Helene M LangevinGary J Badger
Jun 28, 2008·Progress in Neurobiology·Zhi-Qi Zhao
Oct 27, 2010·Evidence-based Complementary and Alternative Medicine : ECAM·Helene M LangevinRichard Hammerschlag
Jul 29, 2011·Pflügers Archiv : European journal of physiology·Geng LiEdward S Yang
Aug 27, 2011·Pflügers Archiv : European journal of physiology·Edward S YangGeng Li
Mar 20, 2012·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Robert T DavisHelene M Langevin
Mar 6, 2013·Journal of Cellular Physiology·Helene M LangevinMaiken Nedergaard
Mar 7, 2013·Cell Calcium·Nanna GoldmanTakahiro Takano
Apr 11, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Shifen XuLixing Lao
Dec 11, 2013·Anesthesiology·Ruixin ZhangBrian M Berman
Aug 21, 2014·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Marcos Dos Santos de AlmeidaEdson Rosa Pimentel
Jul 17, 2015·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Li-Li GaoDong Ming
Sep 6, 2015·International Journal of Dermatology·Sung-Min ParkMargaret Song

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