Safety assessment of the substance benzophenone-3,3',4,4'-tetracarboxylic dianhydride, for use in food contact materials

EFSA Journal
EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP)Gilles Rivière

Abstract

The EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP) assessed the safety of benzophenone-3,3',4,4'-tetracarboxylic dianhydride (BTDA), FCM substance No 1083, as co-monomer for the production of polyimides used in repeated use materials and articles that are in contact with acidic and fatty foods at temperatures up to 250°C. Migration of BTDA from a polyimide containing 43% BTDA, ■■■■■ into olive oil was below the limit of quantification of about 3 μg/kg food, and in 3% acetic acid it decreased from 30.3 μg/kg in the first test to 22.1 μg/kg in the third test (2 h/100°C). In a semi-quantitative screening using acetonitrile and acetonitrile/water to extract the polymer powder, linear and cyclic oligomers were detected at levels below 1 mg/kg material. In thermal desorption of the polymer powder at 250°C, phenol, tentatively identified ■■■■■ were found, but the modelled migrations of these were far below a level of potential concern. ■■■■■. The substance did not induce gene mutations in bacterial and mammalian cells. In an in vitro chromosomal aberration test, the substance was found to be directly clastogenic in the absence of metabolic activation. In an in vivo follow-up, the substance did not induce the f...Continue Reading

References

Jul 7, 2020·EFSA Journal·UNKNOWN EFSA Scientific CommitteeHeather M Wallace

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Methods Mentioned

BETA
chromosomal aberration
chromosomal aberrations
flow cytometry

Software Mentioned

Toxtree

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