Safety Assessment of Water-Extract Sericin from Silkworm (Bombyx mori) Cocoons Using Different Model Approaches.

BioMed Research International
Huiyan QinGuangqiu Qin

Abstract

Sericin is a natural protein component of silks of silkworm and has potential utility in multiple areas such as pharmacological, cosmetics, and biotechnological industries. However, the understanding of its toxicological safety is still limited. This study evaluated the safety of water-extract sericin from silkworm (Bombyx mori) cocoons using different model approaches, including three genotoxicity studies (the bacterial reverse mutation test, the mammalian erythrocyte micronucleus test, and the mouse spermatogonia chromosomal aberration test) and a 90-day subchronic toxicity study in Sprague-Dawley (SD) rats. The results of this study showed that water-extract sericin was nonmutagenic and nongenotoxic both in vitro and in vivo. Sericin did not induce significant changes in the body and organ weight, food intake, blood hematology and serum biochemistry, urine index, and histopathology in rats. The NOAEL of sericin was determined to be 1 g/kg/day for male and female rats. These results indicated that water-extract sericin was of low toxicity in the experimental conditions of the current study and had the potential for application in food-related products.

References

Mar 21, 1998·Bioscience, Biotechnology, and Biochemistry·N KatoM Nomura
May 23, 2001·Pediatrics·J C CeledónS T Weiss
Feb 25, 2003·Bioscience, Biotechnology, and Biochemistry·Yoko TakasuKozo Tsubouchi
Feb 24, 2005·Bioscience, Biotechnology, and Biochemistry·Kozo TsubouchiHiromi Yamada
Feb 14, 2006·Journal of Bioscience and Bioengineering·Satoshi TeradaHideyuki Yamada
Feb 12, 2008·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·You-Gui LiGui-Yan Hu
May 12, 2009·International Journal of Biological Macromolecules·Yong-Juan RenFu-Zhai Cui
Jun 19, 2010·International Journal of Molecular Sciences·Pornanong AramwitTeerapol Srichana
Nov 10, 2010·Journal of Agricultural and Food Chemistry·Nanteetip LimpeanchobManote Sutheerawattananonda
Jan 9, 2015·Indian Journal of Occupational and Environmental Medicine·Giriyanna GowdaChitra Nagaraj
Feb 4, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Ting-Ting Cao, Yu-Qing Zhang
May 4, 2016·Asia Pacific Allergy·Giriyanna GowdaNugehally Raju Ramesh Masthi
Dec 15, 2016·BioMed Research International·Regina Inês KunzMaria Raquel Marçal Natali
Feb 1, 2017·Regulatory Toxicology and Pharmacology : RTP·Guangqiu QinPeng Zhao
Aug 8, 2018·Drug and Chemical Toxicology·Pingjing WenLiang Peng
Nov 20, 2019·International Journal of Biological Macromolecules·Xuan DongYu-Qing Zhang
Dec 14, 2019·Applied Microbiology and Biotechnology·Giorgia Letizia MarconeLoredano Pollegioni
Apr 2, 2020·Drug and Chemical Toxicology·Guangqiu QinKamran Shekh

❮ Previous
Next ❯

Citations

Oct 5, 2021·Naunyn-Schmiedeberg's Archives of Pharmacology·Yasin BagheriSoheila Montazersaheb

❮ Previous
Next ❯

Methods Mentioned

BETA
chromosomal aberration
chromosomal aberrations

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.