Safety, diagnostic accuracy and therapeutic efficacy of digital single-operator cholangioscopy

United European Gastroenterology Journal
Frank LenzeHansjoerg Ullerich

Abstract

Digital single-operator cholangioscopes (digital SOCs), equipped with an improved image quality, have been recently introduced. The aim of this study is to evaluate the safety and diagnostic and therapeutic efficacy of digital SOCs (Spyglass™ DS). Sixty-seven digital SOC procedures performed between 2015 and 2017 were retrospectively analyzed. The most frequent indications for examination were indeterminate biliary strictures (61.2%) and biliary stone disease (23.9%). In 25 patients (37.3), visual findings predicted malignancy with a sensitivity of 88.9%, a specificity of 97.6%, a positive predictive value (PPV) of 96.0% and a negative predictive value (NPV) of 92.9%. For histological analysis, forceps biopsies were performed in 29 patients (43.2%). Compared with visual findings, forceps biopsies yield a lower diagnostic efficacy in diagnosing malignancy (sensitivity 62.5%, specificity 90.0%, PPV 90.9%, NPV 60.0%). Therapeutic interventions were performed in 19 patients with a technical success rate of 89.4%. Adverse events were observed in 17 patients (25.4%). Of these, 11 patients (16.4%) suffered from severe adverse events (pancreatitis, cholangitis or major bleeding), which led to a prolonged hospital stay. Digital SOCs hav...Continue Reading

References

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Citations

Jul 17, 2019·Clinical Endoscopy·Nasim Parsa, Mouen A Khashab
Feb 2, 2019·World Journal of Gastrointestinal Endoscopy·Petko KaragyozovIvan Tishkov
Jun 6, 2019·Current Treatment Options in Gastroenterology·Enrique Pérez-Cuadrado-Robles, Pierre H Deprez
Jul 2, 2020·Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery·Facundo GalettiEduardo Guimarães Hourneaux de Moura
Jul 26, 2019·Current Treatment Options in Gastroenterology·Yusuke IshidaYoshinobu Okabe
Apr 29, 2020·Surgical Endoscopy·Pedro Victor Aniz Gomes de OliveiraEduardo Guimarães Hourneaux de Moura
Nov 26, 2020·Arquivos De Gastroenterologia·Fernanda Prata MartinsAngelo Paulo Ferrari
Sep 8, 2020·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·UNKNOWN Cholangiocarcinoma Working Group
Aug 17, 2021·International Journal of General Medicine·Jinyong Hao, Xiaojun Huang
Jul 25, 2020·Current Drug Metabolism·Manuele FurnariLeonardo Henry Eusebi

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Methods Mentioned

BETA
biopsies
biopsy

Software Mentioned

SPSS Statistics
SpyGlass DS
StatPages

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