Abstract
This study evaluated the effectiveness, safety, and quality of life (Qol) offered by olanzapine in first-episode schizophrenia. One hundred and eighty-two patients with first-episode schizophrenia (ICD-10) drawn from a larger, naturalistic, study were evaluated after 6 months of treatment with olanzapine, risperidone, or conventional antipsychotics (CA). Clinical status was assessed using the Clinical Global Impression-Severity (CGI-S) and Global Assessment of Function (GAF). AWAD and EuroQol scales were used to evaluate patients' attitude towards medication and Qol, respectively. Subjects treated with olanzapine, risperidone, and CA showed similar improvements on CGI-S and GAF. Treatment-emergent, extrapyramidal symptoms were significantly lower in olanzapine-treated patients (17.8%) than in the risperidone (46.4%) and CA (62.2%) groups. Compared to CA, olanzapine and risperidone showed significantly greater improvement on the visual analog scale of EuroQol. Olanzapine-treated patients also showed significantly improved AWAD scores. In first-episode schizophrenia, atypical antipsychotics were effective, and improved Qol. Olanzapine had a lower incidence of extrapyramidal symptoms and better subjective acceptance of medication.
References
Jan 1, 1992·Schizophrenia Bulletin·R RamJ E Schwartz
Jan 1, 1987·Acta Psychiatrica Scandinavica. Supplementum·O LingjaerdeK Elgen
Jan 1, 1988·Schizophrenia Bulletin·T H McGlashan
Feb 1, 1983·Psychological Medicine·T P HoganR Eastwood
Jan 1, 1995·The British Journal of Psychiatry : the Journal of Mental Science·H G HwuL L Yeh
Jan 1, 1994·Acta Psychiatrica Scandinavica. Supplementum·A G Awad, T P Hogan
May 1, 1996·Acta Psychiatrica Scandinavica·J BailerE R Rey
Feb 1, 1996·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·C M BeasleyS Hamilton
Mar 1, 1996·Psychopharmacology·C M BeasleyS Hamilton
Apr 1, 1996·The Netherlands Journal of Medicine·B Blackwell
May 1, 1997·The British Journal of Psychiatry : the Journal of Mental Science·M FranzB Gallhofer
Oct 8, 1997·Journal of Clinical Psychopharmacology·P V TranG D Tollefson
Dec 31, 1997·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S H HamiltonC M Beasley
Sep 24, 1999·Acta Psychiatrica Scandinavica·O Kampman, K Lehtinen
Jun 20, 2000·Schizophrenia Research·L VorugantiA Awad
Dec 16, 2000·Clinical Therapeutics·K A Robinson
May 1, 2001·The American Journal of Psychiatry·R R Conley, R Mahmoud
Citations
Aug 10, 2006·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Stephen M BeardEckart Rüther
Sep 15, 2004·European Psychiatry : the Journal of the Association of European Psychiatrists·Antonio CiudadUNKNOWN EFESO Study Group
May 14, 2005·Psychiatry Research·Michael RitsnerAnatoly Gibel
Jun 1, 2013·Gaceta sanitaria·Lidia García-PérezAmado Rivero-Santana
Jan 4, 2012·L'Encéphale·S BouloudnineE Fakra
Dec 1, 2010·Asian Journal of Psychiatry·Pudtan PhanthunaneMelanie Bertram
Jul 4, 2008·L'Encéphale·J-Y RotgéJ Tignol
Feb 17, 2007·Schizophrenia Research·Peter M WehmeierWolfgang Schreiber
Feb 10, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Peter M WehmeierWolfgang Schreiber
Nov 1, 2008·Early Intervention in Psychiatry·Salvatore De MasiGiovanni De Girolamo
Mar 19, 2009·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Jun Soo Kwon, Jung-Seok Choi
Aug 28, 2007·Journal of Psychiatric Research·Peter M WehmeierMartin Lambert
Dec 2, 2004·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Ruth I OhlsenLyn S Pilowsky
Jul 18, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Michael S Ritsner, Anatoly Gibel
Jan 18, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·S Nassir GhaemiFrederick K Goodwin
May 19, 2012·Expert Opinion on Pharmacotherapy·Stefania RuiuGiorgio Marchese
Jan 1, 2005·International Journal of Psychiatry in Clinical Practice·Martin LambertBenno Graf Schimmelmann
Oct 19, 2006·Journal of Psychopharmacology·Pierre Chue
Sep 16, 2006·Journal of Clinical Psychopharmacology·Bruce J KinonSara Kollack-Walker
Oct 4, 2008·Journal of Psychiatric Practice·Brian J Miller
Jan 1, 2006·International Journal of Psychiatry in Clinical Practice·Tamás TreuerJohn O'Mahoney
Jul 18, 2008·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Jason H KarlawishHenry A Glick
Jun 4, 2005·International Clinical Psychopharmacology·Isabelle GasquetUNKNOWN SOHO Study Group
Dec 6, 2019·Journal of Clinical Psychopharmacology·Nidhi ChauhanSandeep Grover
Dec 5, 2006·European Psychiatry : the Journal of the Association of European Psychiatrists·Hans-Helmut KönigMatthias C Angermeyer
Feb 20, 2004·Pharmacoepidemiology and Drug Safety
Jan 1, 2007·International Journal of Psychiatry in Clinical Practice·Juan Gibert For The Sos Group 1
Aug 2, 2005·The British Journal of Psychiatry : the Journal of Mental Science·Sylvia ParkStephen B Soumerai