Safety evaluation of long term oral treatment of methanol sub-fraction of the seeds of Carica papaya as a male contraceptive in albino rats

Journal of Ethnopharmacology
S GoyalN K Lohiya

Abstract

The manuscript is one of the series of attempts in authenticating scientific documentation of the seeds of Carica papaya being traditionally used for contraception. To establish safety of the methanol sub-fraction (MSF) of the seeds of Carica papaya as a male contraceptive following long term oral treatment. MSF was administered orally to albino rats at multiples of contraceptive dose (CD) at 50 (1x), 100 (2x), 250 (5x) and 500 (10x)mg/kg body weight daily for 52 weeks. Body weight, organs weight, morbidity, mortality, clinical chemistry, sperm analysis, histopathology and serum testosterone were evaluated to assess the safety and contraceptive efficacy. MSF treatment at various dose regimens, daily for 52 weeks did not show significant changes in body weight, organs weight, food and water intake and pre-terminal deaths compared to those of control animals. Sperm count and viability in 50mg/kg body weight treated animals and the weight of epididymis, seminal vesicle and prostate of all the treated animals showed significant reduction compared to control. Cauda epididymal spermatozoa of 50mg/kg body weight treated animals were immotile. Azoospermia was observed in 100, 250 and 500 mg/kg body weight treated animals. Serum clinica...Continue Reading

References

Jan 1, 1994·Reproductive Toxicology·N J ChinoyP Padman
Apr 1, 1957·Archives of Biochemistry and Biophysics·R MONTGOMERY
Jun 1, 1959·Archives of Biochemistry and Biophysics·J S KING, W H BOYCE
May 11, 2004·American Journal of Therapeutics·Kuei-Meng WuKe Zhang
May 13, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C C DeMerlisJ F Borzelleca

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Citations

Oct 15, 2013·Journal of Ethnopharmacology·Zerihun Kebebew, Workineh Shibeshi
May 8, 2016·Journal of Ethnopharmacology·Ashutosh SharmaMaría Luisa Villarreal
Jul 15, 2016·Journal of Immunotoxicology·Saurabh PandeyAmitha K Hewavitharana
Sep 30, 2016·Andrologia·N K LohiyaA S Ansari
Feb 15, 2013·American Journal of Reproductive Immunology : AJRI·Shipra GoyalNirmal K Lohiya
Jan 15, 2021·BMC Complementary Medicine and Therapies·Lubov V KrepkovaElena Y Enioutina

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