Safety evaluation of lotilaner in dogs after oral administration as flavoured chewable tablets (Credelio™)

Parasites & Vectors
E A Kuntz, Srinivas Kammanadiminti

Abstract

Lotilaner (Credelio™, Elanco) is a novel isoxazoline that provides rapid speed of flea and tick knockdown which is sustained for at least 1 month following oral administration to dogs. The safety of lotilaner flavoured chewable tablets was investigated in a randomized, blinded, parallel-group design study in healthy Beagle puppies starting at 8 weeks of age. Lotilaner was administered orally once a month over 8 months at one, three and five times the upper level of the recommended dose range (of 20 to 43 mg/kg). The objective of this study was to determine the safety of lotilaner flavoured chewable tablets in healthy dogs when administered monthly over an extended time period at the highest recommended dose rate, i.e. 1× and at elevated dose rates, i.e. 3× and 5×. Sixteen male and 16 female healthy 8-week-old puppies, weighing ~1.5 to 3.0 kg, were randomized among four groups to be untreated controls or to receive lotilaner at dose rates of 43 mg/kg (1×), 129 mg/kg (3×), or 215 mg/kg (5×) on eight occasions - every 4 weeks over 8 months. The control group was sham-dosed. Study dogs were fed within 30 min prior to treatment. Assessment of safety was based on general health observations, detailed clinical observations, complete p...Continue Reading

References

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Nov 2, 2017·Parasites & Vectors·Céline E ToutainMartin Jung

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Citations

Nov 2, 2017·Parasites & Vectors·Céline E ToutainMartin Jung
Jun 3, 2020·Veterinary Medicine and Science·Valerie PalmieriJon P Kimball
Nov 2, 2017·Parasites & Vectors·Susan E Little
Oct 9, 2020·ChemMedChem·Gulshan Kumar, Ravi Shankar
Mar 19, 2021·Journal of Veterinary Pharmacology and Therapeutics·Xueying ZhouWalter H Hsu

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