Safety evaluation of nanoliposomes containing cyclosporine a after ocular administration

Current Eye Research
Navid MosallaeiBizhan Malaekeh-Nikouei

Abstract

Cyclosporine A (CyA) is an anti inflammatory drug which modulates immune system. We prepared two liposomal formulations of CyA for ophthalmic administration. In the present study, the safety of these formulations was tested in rabbits. Fusogenic and positively charged liposomes were prepared by solvent evaporation method. CyA concentration in ophthalmic preparations was 0.2% w/v. Twenty New Zealand albino rabbits (40 eyes) were divided into two groups. Right eyes were treated and left eyes served as control. Eyes were examined clinically in 1, 3, 7, 14 and 28th days of the study. Eleven eyes were enucleated for pathological evaluation at the end of the study. Mean size and charge of positively charged and fusogenic liposomes were 110.7 ± 1.5 and 114.9 ± 15.2 nm; 19.0 ± 2.2 and 2.5 ± 0.5 mV, respectively. Clinically, there were transient conjunctival injections and corneal epithelial defects in a few cases which were not limited to the treated eyes. Positively charged liposomes caused conjunctival injection in two cases, while this complication occurred in only one eye after administration of fusogenic liposomes. Histopathological examination revealed the presence of follicular conjunctivitis in two eyes with conjunctival inject...Continue Reading

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Citations

Aug 15, 2014·Drug Delivery·Renu AgarwalNafeeza Mohd Ismail
Jan 15, 2016·Drug Delivery and Translational Research·Priyanka Agarwal, Ilva D Rupenthal
Apr 16, 2016·Drug Discovery Today·Priyanka Agarwal, Ilva D Rupenthal

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