Safety evaluation of piperacillin/tazobactam in very low birth weight infants

Journal of Chemotherapy
A BergerA Pollak

Abstract

An open, non-comparative study was designed to evaluate the safety and tolerance of parenteral piperacillin/tazobactam in very low birth weight infants. Twenty-seven patients were included for nosocomial sepsis with gram-negative bacteria (n = 4), nosocomial sepsis not responding to the empirical antibiotic regimen (n = 3), suspected necrotizing enterocolitis (n = 17), and infection after abdominal surgery for reasons other than necrotizing enterocolitis (n = 3). No clinical adverse events considered related to the study drug were noted, in particular, no cases of phlebitis, rash or stool changes. Several possibly related, mild and transitory abnormalities of laboratory parameters were observed. No long-lasting effect on the intestinal flora was detected. Seventeen patients (63%) were considered to have a favorable clinical response. This study demonstrates that piperacillin/tazobactam is a safe and well tolerated drug for preterm infants with bacterial infections, particularly those involving the gastrointestinal tract. Comparative clinical trials are warranted to further clarify the microbiological efficacy of piperacillin/tazobactam in this particular patient population.

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Citations

Sep 6, 2007·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A SimonH J Laws
Feb 25, 2009·Expert Opinion on Drug Metabolism & Toxicology·Maria F Wolf, Arne Simon
Feb 21, 2007·Journal of Chemotherapy·V FanosM Testa
Feb 14, 2015·Clinics in Perinatology·Leslie C Pineda, Kevin M Watt
Jul 31, 2016·Clinical Therapeutics·Jacob K Johnson, Matthew M Laughon
Mar 13, 2014·Antimicrobial Agents and Chemotherapy·Michael Cohen-WolkowiezP Brian Smith
Aug 2, 2017·Future Microbiology·Nazario D Rivera-ChaparroRachel G Greenberg
Mar 1, 2008·British Journal of Clinical Pharmacology·Halima MaulidiPeter Chow
Apr 15, 2017·The Pediatric Infectious Disease Journal·Sara SalernoUNKNOWN Best Pharmaceuticals for Children Act–Pediatric Trials Network Steering Committee
Aug 28, 2021·British Journal of Clinical Pharmacology·Yue-E WuWei Zhao

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