Safety evaluation of proanthocyanidin polymer-rich fraction obtained from stem bark of Stryphnodendron adstringens (BARBATIMAO) for use as a pharmacological agent

Regulatory Toxicology and Pharmacology : RTP
Marco Antonio CostaCelso Vataru Nakamura

Abstract

The widespread use of medicinal plants among the Brazilian population warrants an assessment of the potential risks associated with their intake. Stryphnodendron adstringens (barbatimão) is one of the most frequently used medicinal plants in Brazil, and the risks associated with its use have yet to be investigated. This study evaluated the genotoxic safety of the use of the proanthocyanidin polymer-rich fraction (F2) of stem bark of S. adstringens. The micronucleus test with 750, 1500, and 2250 mg kg(-1) of F2 administered in Mus musculus (Swiss) outbred mice, showed respectively, 5.0±0.8 (Mean±S.D.), 9.1±1.7, and 10.6±1.9 micronucleated polychromatic erythrocytes (MNPCE). A positive control with cyclophosphamide resulted in 21.0±3.8 MNPCE. Antimutagenicity was also evaluated, by adding 750 mg kg(-1) to cyclophosphamide; the result of 8.7±1.4 showed a protective cytotoxic effect. For the Artemia salina test, 10, 100, and 1000 mg L(-1) of F2 showed, respectively, 8.7±0.6, 7.7±0.6, and 5.7±1.2 survival, i.e., F2 did not inhibit 50% of the population when compared to the control (9.7±0.6). These results indicated that F2 obtained from stem bark of S. adstringens has no genotoxic activity.

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Citations

Jun 11, 2014·BMC Microbiology·Tatiana Shioji TiumanCelso Vataru Nakamura
Aug 25, 2015·Journal of Ethnopharmacology·Tânia M Antonelli-UshirobiraJoão C P de Mello
Dec 19, 2015·Journal of Ethnopharmacology·Graziela SponchiadoMichel Fleith Otuki
Aug 24, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Marco Antonio CostaCelso Vataru Nakamura
Apr 18, 2015·BMC Complementary and Alternative Medicine·Raul Leal Faria LuizKelly Ishida
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Jul 21, 2011·Experimental Parasitology·Adriana Oliveira dos SantosCelso Vataru Nakamura
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Apr 18, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tatiana M Souza-MoreiraRosemeire C L R Pietro
May 12, 2018·BioMed Research International·Lingyu YangJianqiao Zhong

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