Safety, feasibility, and potential efficacy of intraarterial selective cooling infusion for stroke patients treated with mechanical thrombectomy

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Chuanjie WuXunming Ji

Abstract

This is a prospective non-randomized cohort study of 113 consecutive patients to investigate the safety and efficacy of a short-duration intraarterial selective cooling infusion (IA-SCI) targeted into an ischemic territory combined with mechanical thrombectomy (MT) in patients with large vessel occlusion-induced acute ischemic stroke (AIS); 45/113 patients underwent IA-SCI with 350 ml 0.9% saline at 4℃ for 15 min at the discretion of the interventionalist. Key parameters such as vital signs and key laboratory values, symptomatic and any intracranial hemorrhage, coagulation abnormalities, pneumonia, urinary tract infections and mortality were not significantly different between the two groups. Final infarct volume (FIV) was assessed on noncontrast CT performed at three to seven days. After an adjusted regression analysis, the between-group difference in FIV (19.1 ml; 95% confidence interval (CI) 3.2 to 25.2; P = 0.038) significantly favored the IA-SCI group. At 90 days, no differences were found in the proportion of patients who achieved functional independence (mRS 0-2) (51.1% versus. 41.2%, adjusted odd ratio (aOR) 1.9, 95% CI 0.8-2.6, P = 0.192). Combining short-duration IA-SCI with MT was safe. There was a smaller FIV and tr...Continue Reading

References

Jul 1, 1989·Stroke; a Journal of Cerebral Circulation·T BrottM Walker
May 1, 1988·Stroke; a Journal of Cerebral Circulation·J C van SwietenJ van Gijn
Feb 7, 2001·Stroke; a Journal of Cerebral Circulation·H B van der WorpL J Kappelle
Sep 8, 2001·Stroke; a Journal of Cerebral Circulation·S SchwabS A Mayer
Sep 7, 2002·Stroke; a Journal of Cerebral Circulation·J T Lindsay WilsonIan Bone
Dec 16, 2006·Journal of Applied Physiology·Angelos-Aristeidis KonstasJohn Pile-Spellman
Sep 26, 2008·The New England Journal of Medicine·Werner HackeUNKNOWN ECASS Investigators
Jan 8, 2010·AJNR. American Journal of Neuroradiology·J H ChoiJ Pile-Spellman
Jan 3, 2013·Acta Neurologica Scandinavica·C OvesenJ Petersson
Feb 19, 2013·Lancet Neurology·Tzu-Ching Wu, James C Grotta
Aug 8, 2013·Stroke; a Journal of Cerebral Circulation·Osama O ZaidatUNKNOWN STIR Thrombolysis in Cerebral Infarction (TICI) Task Force
Nov 10, 2013·Stroke; a Journal of Cerebral Circulation·Ji Man HongKiwon Lee
Jan 18, 2014·Stroke; a Journal of Cerebral Circulation·Katja PiironenMarkku Kaste
Dec 18, 2014·The New England Journal of Medicine·Olvert A BerkhemerUNKNOWN MR CLEAN Investigators
Feb 12, 2015·The New England Journal of Medicine·Bruce C V CampbellUNKNOWN EXTEND-IA Investigators
Feb 12, 2015·The New England Journal of Medicine·Mayank GoyalUNKNOWN ESCAPE Trial Investigators
Apr 18, 2015·The New England Journal of Medicine·Jeffrey L SaverUNKNOWN SWIFT PRIME Investigators
Apr 18, 2015·The New England Journal of Medicine·Tudor G JovinUNKNOWN REVASCAT Trial Investigators
Jun 10, 2015·Experimental Neurology·Ziping HanXunming Ji
May 21, 2016·Stroke; a Journal of Cerebral Circulation·Jian ChenXunming Ji

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Citations

Jul 18, 2019·Journal of Neurotrauma·John J WalshDaniel Coman
Dec 1, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Eng H Lo, Michael A Moskowitz
Dec 31, 2019·Stroke; a Journal of Cerebral Circulation·Yunxia DuanXunming Ji
Aug 1, 2019·Journal of Neurointerventional Surgery·Jildaz CaroffMatthew J Gounis
Feb 28, 2020·Stroke; a Journal of Cerebral Circulation·William K DiproseP Alan Barber
May 20, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Anna Luisa KühnMatthew J Gounis
May 20, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Patrick Lyden
Jul 4, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Longfei WuXunming Ji
Oct 16, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Klaus van LeyenEng H Lo
Jan 18, 2020·Brain Circulation·Bridget C VaughanRobert D Schultz
Mar 5, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Di WuXunming Ji
Jan 18, 2020·Brain Circulation·Thomas L MerrillAngelos A Konstas
Jan 18, 2020·Brain Circulation·Chuanjie WuXunming Ji
Jan 18, 2020·Brain Circulation·Thomas K Mattingly, Stephen P Lownie
Apr 30, 2019·Neurological Research·Yun HanXiaokun Geng
Jul 25, 2019·Brain Circulation·Andrea M KuczynskiMohammed A Almekhlafi
May 7, 2020·Current Neurology and Neuroscience Reports·Andrea M KuczynskiMohammed A Almekhlafi
Dec 21, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Longfei WuXunming Ji
Jul 28, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Di WuXunming Ji
Dec 8, 2020·Frontiers in Neurology·Jae H ChoiJohn Pile-Spellman
Feb 9, 2021·Frontiers in Neurology·Nathanael MateiJohn H Zhang
Jun 5, 2021·AJNR. American Journal of Neuroradiology·F BalaM A Almekhlafi
May 12, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Christian HartmannVolker Puetz
Jul 8, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Alba GraystonAnna Rosell
Jul 23, 2021·Stroke; a Journal of Cerebral Circulation·Patrick D Lyden
Jun 24, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Giorgio Fm CattaneoStephan Meckel
Jan 20, 2022·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Luling WangXunming Ji

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Clinical Trials Mentioned

NCT03163459

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SPSS

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