Safety issues from a Phase 3 clinical trial of a live-attenuated chimeric yellow fever tetravalent dengue vaccine

Human Vaccines & Immunotherapeutics
Scott B Halstead

Abstract

A tetravalent live-attenuated 3-dose vaccine composed of chimeras of yellow fever 17D and the four dengue viruses (CYD, also called Dengvaxia) completed phase 3 clinical testing in over 35,000 children leading to a recommendation that vaccine be administered to >/ = 9 year-olds residing in highly dengue- endemic countries. When clinical trial results were assessed 2 years after the first dose, vaccine efficacy among seropositives was high, but among seronegatives efficacy was marginal. Breakthrough dengue hospitalizations of vaccinated children occurred continuously over a period of 4-5 years post 3rd dose in an age distribution suggesting these children had been vaccinated when seronegative. This surmise was validated recently when the manufacturer reported that dengue NS1 IgG antibodies were absent in sera from hospitalized vaccinated children, an observation consistent with their having received Dengvaxia when seronegative. Based upon published efficacy data and in compliance with initial published recommendations by the manufacturer and WHO the Philippine government undertook to vaccinate 800,000-plus 9 year-olds starting in April 2016. Eighteen months later, dengue hospitalizations and a deaths were reported among vaccinat...Continue Reading

References

Dec 25, 2002·Emerging Infectious Diseases·Scott B HalsteadTimothy P Endy
Dec 24, 2003·Advances in Virus Research·Scott B Halstead
Nov 5, 2014·The New England Journal of Medicine·Luis VillarUNKNOWN CYD15 Study Group
Jul 28, 2015·The New England Journal of Medicine·Sri Rezeki HadinegoroUNKNOWN CYD-TDV Dengue Vaccine Working Group
Dec 8, 2015·Nature Reviews. Microbiology·Bruno Guy, Nicholas Jackson
Feb 14, 2016·Vaccine·Scott B Halstead, Philip K Russell
Jun 30, 2016·The American Journal of Tropical Medicine and Hygiene·Scott B Halstead
Aug 9, 2016·The Journal of Infectious Diseases·Scott B Halstead
Aug 9, 2016·The Journal of Infectious Diseases·Annelies Wilder-SmithTerry Nolan
Aug 12, 2016·PLoS Neglected Tropical Diseases·Philip K Russell, Scott B Halstead
Oct 4, 2016·The Journal of Infectious Diseases·Scott B Halstead
Feb 12, 2017·Vaccine· World Health Organization
Jun 18, 2017·Vaccine·Ruth Aralí Martínez-VegaJosé Ramos-Castañeda

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Citations

Jun 21, 2018·The Journal of General Virology·J L Slon CamposO R Burrone
Oct 1, 2019·Immunity, Inflammation and Disease·Dulharie T WijeratneGathsaurie N Malavige
Jan 26, 2020·BMJ : British Medical Journal·Peter AabyChristine Stabell Benn
Jan 15, 2020·Antimicrobial Agents and Chemotherapy·Antonios FikatasDominique Schols
Jun 4, 2020·Vaccines·Aryamav PattnaikAsit K Pattnaik
Jul 5, 2019·The Journal of Experimental Medicine·Nicholas HernandezXavier Bossuyt
Oct 5, 2018·Frontiers in Immunology·Susanne RauchBenjamin Petsch
Apr 10, 2019·Tropical Medicine and Infectious Disease·In-Jeong KimJr-Shiuan Lin
Apr 24, 2019·Tropical Medicine and Infectious Disease·Matthew H Collins
Dec 21, 2018·Frontiers in Microbiology·Maria K SmattiHadi M Yassine
Jun 9, 2020·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Henning UlrichAttila Tárnok
Jul 14, 2020·Vaccine·Scott B HalsteadAntonio L Dans
Sep 1, 2019·Travel Medicine and Infectious Disease·Scott B Halstead
Dec 6, 2019·Chemical Reviews·Ryan J MalonisOlivia Vergnolle
Jan 23, 2021·RSC Medicinal Chemistry·Fumiaki Yokokawa
Mar 30, 2020·The Lancet Infectious Diseases·Arturo Reyes-Sandoval
Feb 20, 2021·Virus Research·Debajit DeyS Saif Hasan
Jul 3, 2021·Life·Rong ZhaoJimin Cao
Sep 25, 2019·Journal of Medicinal Chemistry·Jean A BernatchezRongshi Li
Oct 7, 2021·Scientific Reports·Adewale Oluwaseun FadakaMervin Meyer

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