Safety limit of the extent of hepatectomy for rats with moderately fatty liver: experimental study concerning living liver donor safety

Journal of Gastroenterology and Hepatology
Daisuke MoriokaHiroshi Shimada

Abstract

The aim of the present study was to determine whether rats with moderately fatty liver could withstand a 90% hepatectomy, which rats with normal livers can survive. Nine-week-old male Wistar rats were used. Normal rat chow was fed to the normal liver group, and fat-enriched rat chow was fed to the fatty liver group for 4 weeks to induce a moderately fatty liver. The authors have previously reported that this fatty liver rat model can cause fatal liver dysfunction after reduced-size-liver transplantation. A 90% and 95% hepatectomy were performed using rats of both groups to evaluate posthepatectomized liver function. All rats undergoing a 90% hepatectomy were still alive 30 days after the hepatectomy, but the rats that underwent a 95% hepatectomy were all dead within 4 days regardless of group. Increases in the liver remnant wet weight measured until 7 postoperative days after 90% hepatectomy were almost similar among the two groups. Alanin aminotransferase measured at 24, 48, 72, and 168 h after a 90% hepatectomy were significantly higher in the fatty liver group than in the normal liver group. Similarly, at up to 72 h postoperatively, the serum hyarulonic acids were significantly higher in the fatty liver group. A moderately f...Continue Reading

References

Jan 1, 1977·Scandinavian Journal of Gastroenterology·M KekkiM Siurala
Jan 1, 1977·Scandinavian Journal of Gastroenterology·M HildenJ B Dalgaard
Dec 1, 1993·Transplantation·R S MarkinB W Shaw
Apr 15, 1995·Transplantation·B KoneruR J Ferrante
Sep 2, 1998·Transplantation Proceedings·B NardoA Cavallari
Dec 8, 1998·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·K E BehrnsD M Nagorney
Mar 20, 1999·Transplantation Proceedings·T FukumoriS Satomi
Mar 30, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A RashidA M Diehl
Nov 7, 1999·Transplant International : Official Journal of the European Society for Organ Transplantation·P SchemmerR G Thurman
Dec 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M Selzner, P A Clavien
Feb 24, 2001·Seminars in Liver Disease·J F Renz, R W Busuttil
May 8, 2001·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·N KamimukaiH Shimada
May 24, 2001·The New England Journal of Medicine·D C CroninM Siegler
Sep 29, 2001·Digestive Diseases and Sciences·M S RaoT Hashimoto
Feb 28, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Mitchell L ShiffmanJay H Hoofnagle
May 11, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Charles J ImberPeter J Friend
Jul 11, 2002·The American Journal of Pathology·Michael TorbensonAnna Mae Diehl
Dec 31, 2002·Lancet·Hiroshi ImamuraMasatoshi Makuuchi
Jan 7, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Daisuke MoriokaHiroshi Shimada
Jul 29, 2003·Transplantation·Yuji SoejimaKeizo Sugimachi
May 27, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Hiroshi ImamuraMasatoshi Makuuchi

❮ Previous
Next ❯

Citations

Jun 11, 2008·The Journal of Surgical Research·Chenghu MaHiroyuki Kuwano
Apr 9, 2008·The Journal of Surgical Research·Uta DahmenOlaf Dirsch
Mar 8, 2006·The Journal of Surgical Research·Shuji SaitoHiroshi Shimada

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Surgical Research
Hirochika MakinoHiroshi Shimada
Current Opinion in Critical Care
O N Tucker, N Heaton
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
J Gaub, J Iversen
© 2021 Meta ULC. All rights reserved