Safety of a new spray-type adhesion barrier (AdSpray® ) in liver surgery.

Journal of Hepato-biliary-pancreatic Sciences
Satoshi OkuboMasaji Hashimoto

Abstract

Although adhesion barriers are increasingly used in liver surgery, there are no sufficient data yet in support of their safety. Data of 104 consecutive patients in whom a spray-type adhesion barrier (AdSpray® ) was used after hepatectomy were compared with those of 94 control subjects in whom no adhesion barriers were used, and the risk factors for major morbidity after hepatectomy were investigated. The incidence of major morbidity was not significantly different between the AdSpray group and the control group (17% vs 15%, P = .645), although multivariate analyses revealed that the use of AdSpray was associated with an increased risk of abdominal abscess (odds ratio [OR], 4.42; P = .043). Similar tendency was also confirmed after propensity score adjustment to account for the potential selection bias. A sub-group analysis revealed that incidence of abscess formation decreased as operators' experience in the used of AdSpray increased, and multivariate analysis identified preoperative chemotherapy (OR, 3.96; P = .043) as being independent predictors of abscess formation after the use of AdSpray. AdSpray use was not associated with global incidence of major morbidity after liver surgery, although surgeon's experience would be nee...Continue Reading

References

Oct 8, 2003·Diseases of the Colon and Rectum·David E BeckUNKNOWN Adhesion Study Group Steering Committee
Jul 30, 2009·Annals of Surgery·Pierre A ClavienMasatoshi Makuuchi
Jul 27, 2017·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Takeshi SutoMasafumi Inomata
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Feb 26, 2019·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Eva BraunwarthStefan Stättner

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Citations

Jan 20, 2021·Macromolecular Bioscience·Arvind K Singh ChandelTaichi Ito
Sep 2, 2020·Acta Biomaterialia·Jingyi TangShengfu Chen
Aug 30, 2020·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Satoshi OkuboMasaji Hashimoto
Aug 27, 2021·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Daisuke HokkaYoshimasa Maniwa

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