Abstract
There is limited evidence relating to the impact of disease modifying anti-rheumatic drugs (DMARDs) upon male fertility and peri-conception paternal exposure in men with rheumatic disease. Therefore, we conducted a systematic review of available evidence to update information on this subject and guide paternal counselling. A systematic search of PubMed and Embase was carried out up to September 2017, to find relevant peer-reviewed papers, using keywords for fertility/spermatogenesis/conception, men, and disease modifying or biologic drugs commonly prescribed in patients with rheumatic disease. The search yielded 724 papers, and the titles/abstracts were screened independently by 2 authors, duplicates removed and 233 potentially relevant papers selected for full text review. A total of 84 papers were included in the final analysis which covered the impact on fertility of over 611 male exposures to relevant drugs, and over 5986 pregnancies conceived during paternal exposure to (or within 3 months of stopping) these drugs. Aside from the known adverse impact of cyclophosphamide and sulfasalazine on spermatogenesis, overall there was no firm evidence of harm to fertility or pregnancy outcomes with paternal exposure to anti-TNF ther...Continue Reading
Citations
Mar 7, 2019·Current Rheumatology Reports·Nicole Hunt, Mehret Birru Talabi
Aug 10, 2019·Transplantation·Anupam ChandraIvar Anders Eide
Dec 13, 2019·Zeitschrift für Rheumatologie·R Fischer-Betz, S Späthling-Mestekemper
Feb 6, 2020·The American Journal of Gastroenterology·Muhammad B Hammami, Uma Mahadevan
Aug 1, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·J L W LambertR Speeckaert
Nov 5, 2019·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Anja GeldhofDanielle Coppola
Sep 19, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Monika SarkarNorah A Terrault
Jan 10, 2021·RMD Open·Nadia M T RoodenrijsPaco M J Welsing
Jan 16, 2021·Clinical Rheumatology·Yasser El Miedany, Deborah Palmer
Feb 7, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·A NastC Dressler
Oct 6, 2020·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Tsen-Fang TsaiUNKNOWN Taiwan Rheumatology Association (TRA) and the Taiwanese Association for Psoriasis and Skin Immunology (TAPSI)
Apr 4, 2021·International Journal of Molecular Sciences·Katarzyna Romanowska-PróchnickaDariusz Szukiewicz
Mar 22, 2021·Gastroenterology·Joseph MeserveSiddharth Singh
May 14, 2021·Expert Review of Clinical Pharmacology·Rebecca Fischer-Betz, Monika Østensen
Jun 15, 2021·Frontiers in Pharmacology·Asmaa BeltagyPier Luigi Meroni
Aug 20, 2021·Annals of the Rheumatic Diseases·György NagyJacob M van Laar