Safety of carbon dioxide insufflation for upper gastrointestinal tract endoscopic treatment of patients under deep sedation.

Surgical Endoscopy
Satoru NonakaIchiro Oda

Abstract

It is well known that carbon dioxide (CO(2)) is absorbed faster in the body than air and also that it is rapidly excreted through respiration. This study aimed to investigate the safety of CO(2) insufflation used for esophageal and gastric endoscopic submucosal dissection (ESD) in patients under deep sedation. Patients with either early gastric or esophageal cancers that could be resected by ESD were enrolled in this study from March 2007 to July 2008 and randomly assigned to undergo ESD procedures with CO(2) insufflation (CO(2) group) or air insufflation (air group). A TOSCA measurement system and TOSCA 500 monitor were used to measure and monitor both transcutaneous partial pressure of CO(2) (PtcCO(2)) and oxygen saturation (SpO(2)). The study enrolled 89 patients and randomly assigned them to a CO(2) group (45 patients) or an air group (44 patients). The mean CO(2) group versus air group measurements were as follows: PtcCO(2) (49.1 +/- 5.0 vs. 50.1 +/- 5.3 mmHg; nonsignificant difference [NS]), maximum PtcCO(2) (55.1 +/- 6.5 vs. 56.8 +/- 7.0 mmHg; NS), PtcCO(2) elevation (9.1 +/- 5.4 vs. 11.4 +/- 5.6 mmHg; p = 0.054), SpO(2) (99.0 +/- 0.7% vs. 99.0 +/- 1.0%; NS), minimum SpO(2) (96.5 +/- 2.4% vs. 95.4 +/- 3.3%; p = 0.085), a...Continue Reading

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Citations

Jul 5, 2011·Journal of Gastroenterology and Hepatology·Hirohito MoriTsutomu Masaki
May 2, 2012·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Ichiro OdaShigetaka Yoshinaga
Jan 5, 2013·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Federico SoriaRafael Latorre
Feb 2, 2013·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Ichiro OdaShigetaka Yoshinaga
Aug 26, 2011·World Journal of Gastrointestinal Endoscopy·Hiroki HongouSumio Watanabe
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Apr 1, 2014·Gastrointestinal Endoscopy Clinics of North America·Takuji GotodaPeter Draganov
Sep 26, 2013·Gastrointestinal Endoscopy·Satoru NonakaYutaka Saito
Apr 10, 2013·Gastrointestinal Endoscopy·Satoru NonakaYutaka Saito
Jul 4, 2012·Annales Françaises D'anesthèsie Et De Rèanimation·L RamirezN Pichon
Mar 8, 2016·Gastrointestinal Endoscopy·UNKNOWN ASGE Technology CommitteeSubhas Banerjee
May 16, 2013·Orthopedics·Asode Ananthram ShettyDavid Stelzeneder
Jan 1, 2014·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Gottumukkala S Raju
Jun 19, 2013·World Journal of Gastrointestinal Endoscopy·Jiro WatariHiroto Miwa
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Jul 18, 2015·World Journal of Gastroenterology : WJG·Jun TakadaHisataka Moriwaki
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Sep 5, 2020·Lung India : Official Organ of Indian Chest Society·Scott A HelgesonNeal M Patel
Sep 19, 2014·World Journal of Gastroenterology : WJG·Shinsuke KiriyamaHiroyuki Kuwano

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