Abstract
To evaluate the safety of diphtheria-tetanus-acellular pertussis-inactivated polio-Haemophilus influenzae type B (DTaP-IPV-HIB) immunization in premature infants. Observational study of 78 very low birth weight premature infants (mean gestational age, 28+/-2 weeks; mean birth weight, 1045+/-357 g) given DTaP-IPV-HIB vaccine before hospital discharge. Apnea, bradycardia, oxygen requirements and saturation, feeding practice, and medical interventions were assessed before and after immunization. The results were analyzed by the severity of the clinical condition and the persistence of prematurity-associated symptoms. Administration of DTaP-IPV-HIB elicited resurgence or increase in cardiorespiratory events in 47% of infants (15% had apnea, 21% had bradycardia, 42% of desaturations). Most vaccine-triggered events resolved spontaneously or after brief stimulation. The relative risk was 5- to 8-fold higher in infants with a severe clinical course or persistence of cardiorespiratory symptoms at the time of immunization. Bag-mask respiratory support was given to 5 of 78 infants, and O(2) requirements increased transiently in 4 of 21 infants with chronic lung disease, none requiring reventilation. Reintroduction of O(2) supplementation,...Continue Reading
References
May 1, 1988·Archives of Disease in Childhood·J Roper, S Day
Aug 1, 1985·Archives of Surgery·D B GroffJ B Pietsch
Dec 1, 1994·Journal of Paediatrics and Child Health·S J Botham, D Isaacs
May 1, 1997·The Journal of Pediatrics·P J SánchezJ M Perlman
Mar 11, 1998·Pediatrics·M PourcyrousH S Bada
Jul 31, 1998·The New England Journal of Medicine·R L Goldenberg, D J Rouse
May 1, 1999·Pediatrics·R L SchloesserS Zielen
May 14, 1999·American Family Physician
Jun 22, 1999·Archives of Disease in Childhood. Fetal and Neonatal Edition·M H Slack, D Schapira
Sep 24, 1999·The Pediatric Infectious Disease Journal·C T D'Angio
Feb 15, 2001·Archives of Pediatrics & Adolescent Medicine·D L LangkampS Lemeshow
May 4, 2001·MMWR. Recommendations and Reports : Morbidity and Mortality Weekly Report. Recommendations and Reports·C B BridgesUNKNOWN Advisory Committee on Immunization Practices
Jun 13, 2001·American Journal of Respiratory and Critical Care Medicine·A H Jobe, E Bancalari
Sep 1, 2001·Acta Paediatrica·S SenP Buss
Dec 6, 2001·American Journal of Respiratory and Critical Care Medicine·S H Abman
Jan 2, 2003·Pediatrics·Greg R AlexanderJoanne Mor
Jul 13, 2006·Journal of Pediatric Health Care : Official Publication of National Association of Pediatric Nurse Associates & Practitioners·Thad R Wilson
Nov 20, 2015·Journal of Perinatology : Official Journal of the California Perinatal Association·J M Di FioreP MacFarlane
Citations
Apr 22, 2005·European Journal of Pediatrics·Sven SchulzkeHubert Fahnenstich
Jul 27, 2010·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·J GaudelusE Lachassinne
Sep 10, 2010·Journal of Paediatrics and Child Health·Douglas F HackingJodie McVernon
Oct 24, 2006·Archives of Disease in Childhood·J BonhoefferP T Heath
Jun 21, 2006·BMC Pediatrics·Jackie LeeDonald W Spady
Aug 28, 2009·Journal of Perinatology : Official Journal of the California Perinatal Association·A K FurckE Kattner
Feb 26, 2010·Journal of Perinatology : Official Journal of the California Perinatal Association·A M Navar-BogganN P Klein
Aug 2, 2011·Vaccine·Ewa Szynczewska, Danuta Chlebna-Sokół
Jun 23, 2011·Vaccine·Vanessa CliffordJim P Buttery
Feb 20, 2016·Archives of Disease in Childhood·Andrew James McArdleDieudonne Birahinduka
Aug 23, 2008·The Journal of Pediatrics·Aline Flatz-JequierClaire-Anne Siegrist
May 21, 2008·Vaccine·Peter A CooperKeith P Klugman
Dec 25, 2007·The Lancet Infectious Diseases·Klara M Posfay-BarbeDidier Pittet
Jul 24, 2007·The Journal of Pediatrics·Massroor PourcyrousHenrietta S Bada
May 21, 2008·Acta Paediatrica·Liliana VázquezLode Schuerman
Feb 27, 2013·Journal of Paediatrics and Child Health·Jemma AndersonScott A Morris
Nov 19, 2011·Pediatric Transplantation·A G L'HuillierK M Posfay-Barbe
Nov 8, 2006·Vaccine·Giacomo FaldellaRosina Alessandroni
Aug 21, 2015·Human Vaccines & Immunotherapeutics·Arnaud GagneurCaroline Quach
Aug 25, 2015·Vaccine·Samuel ThrallCaroline Quach
Aug 5, 2020·Human Vaccines & Immunotherapeutics·Marissa B WilckAndrew W Lee
Apr 7, 2019·Expert Review of Vaccines·Elena ChiappiniGian Luigi Marseglia
Oct 2, 2020·Expert Review of Vaccines·Yuyang XuJunfang Chen
Jun 28, 2017·The Pediatric Infectious Disease Journal·Wissal Ben JmaaAnne Monique Nuyt
Dec 3, 2020·NeoReviews·Asimenia Angelidou, Ofer Levy
Aug 29, 2021·Vaccines·Bettina BohnhorstSabine Pirr
Aug 31, 2021·Journal of Neonatal-perinatal Medicine·B SullivanK D Fairchild
Jun 1, 2016·Pediatrics·Edwin Clark MontagueAnthony J Piazza
Mar 4, 2008·Pediatrics·Nicola P KleinUNKNOWN Vaccine Safety Datalink
May 3, 2008·Pediatrics·Tracy CarboneNilima Karamchandani
Dec 3, 2005·Pediatrics·Felix OmeñacaRafael Dal-Ré