Safety of dual kidney transplantation compared to single kidney transplantation from expanded criteria donors: a single center cohort study of 39 recipients

Transplant International : Official Journal of the European Society for Organ Transplantation
Lionel MendelDaniel Chevallier

Abstract

Our objective was to compare the outcomes of dual kidney transplanataion (DKT) to single kidney transplantation (SKT) performed with grafts from expanded criteria donors (ECD) in recipients ≥65 years, focusing on surgical complications. All kidney transplantations (KT) performed between 2006 and 2014 in our institution were analysed. DKT was indicated according to the criteria of the French national Agence de la Biomedecine. Thirty-nine DKT and 155 SKT were included, with a median follow-up of 36 and 26.5 months, respectively. The rate of early surgical revisions was not significantly higher after DKT (23.1% vs 15.5% (P = 0.2593)) but more venous graft thromboses (12.8% vs 3.2% (P = 0.02)) were reported. The glomerular filtration rate (GFR) 24 months after KT was significantly higher after DKT (45.0 ± 16.3 vs 39.8 ± 13.8 ml/min/1.73m2 ; P = 0.04) and allowed shorter waiting time without a significant increased risk of surgical revision, excepted for venous graft thrombosis, more frequent after DKT. Graft survivals were not significantly different and GFR was higher after DKT. DKT seems to remain an appropriate strategy to address the growing graft shortage in elderly patients.

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Citations

Nov 24, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Maria IbrahimDarren Stewart
Jan 18, 2020·Transplantation Reviews·Brian CamilleriAhmed Halawa
Dec 2, 2020·American Journal of Surgery·Giovanni VarottiIris Fontana
Oct 12, 2021·Clinical Transplantation·Rossella GiocoMassimiliano Veroux
Dec 24, 2021·Current Opinion in Organ Transplantation·Robert J StrattaBerjesh Sharda
Dec 23, 2021·Clinical Transplantation·Robert J StrattaBerjesh Sharda

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