Safety of ferumoxytol in children undergoing cardiac MRI under general anaesthesia

Cardiology in the Young
Lisa Wise-FaberowskiChandra Ramamoorthy

Abstract

Ferumoxytol, an "off-label" contrast agent, allows for better cardiac MRI quality as compared with gadolinium-based contrast agents. However, hypotension has been reported with the use of ferumoxytol for indications other than cardiac MRI. The purpose of our investigation was to evaluate the safety of ferumoxytol in children undergoing general anaesthesia for cardiac MRI. Medical records of children undergoing general anaesthesia for cardiac MRI were reviewed. Baseline demographic and medical characteristics, as well as imaging and anaesthetic duration and technique, were collected. The incidence of hypotension or other adverse events', need for vasoactive support, or airway intervention throughout the anaesthetic, was recorded. A total of 95 patients were identified, 61 received ferumoxytol and 34 received gadolinium. There were no significant differences between groups with respect to age, weight, or baseline blood pressure. The incidence of low blood pressure - systolic or mean - after contrast administration did not differ between groups, and there was no difference in sustained hypotension or use of vasopressors between groups. One patient who received ferumoxytol had possible anaphylaxis. The image acquisition time (45 ve...Continue Reading

References

Aug 10, 2000·Journal of Magnetic Resonance Imaging : JMRI·V M Runge
Sep 25, 2007·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Adam L DorfmanTal Geva
Nov 22, 2007·AJR. American Journal of Roentgenology·Jonathan R DillmanSophia C Jan
Mar 19, 2008·The Journal of Pediatrics·Mark A FogelMikael Concepcion
Jun 6, 2008·Journal of the American Society of Nephrology : JASN·Bruce S SpinowitzBrian J G Pereira
Jan 1, 2008·Seminars in Thoracic and Cardiovascular Surgery·Frandics P Chan
Jul 28, 2010·American Journal of Hematology·Diane K WysowskiCatherine Dormitzer
Nov 26, 2011·The Annals of Pharmacotherapy·Nabil HassanKaren Kovey
Oct 17, 2012·Investigative Radiology·Pippa StoreyVivian S Lee
Nov 28, 2012·Pediatric Radiology·Rini JainJana A Stockwell
Mar 15, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Csanad G VarallyayEdward A Neuwelt
Sep 13, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Anjali B NayakJoshua Zaritsky
Nov 28, 2014·Pediatric Radiology·Nichanan RuangwattanapaisarnShreyas S Vasanawala
Feb 25, 2015·Journal of Magnetic Resonance Imaging : JMRI·Shreyas S VasanawalaAlbert Hsiao
Mar 6, 2015·Radiology·Robert J McDonaldLaurence J Eckel
Mar 25, 2015·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Susann NeiserSusanna Burckhardt
Sep 17, 2015·Pediatric Blood & Cancer·Elpis Mantadakis
Dec 10, 2015·Journal of Magnetic Resonance Imaging : JMRI·Joseph Y ChengShreyas S Vasanawala
Feb 20, 2016·Journal of the American College of Cardiology·David FaraoniJames A DiNardo

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Citations

Oct 25, 2020·Journal of Magnetic Resonance Imaging : JMRI·Faraz AhmadNicola Schieda
May 4, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Dominie L MiyasatoCristina Zavaleta
May 8, 2021·Skeletal Radiology·Sophie C QuelerDarryl B Sneag

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