Safety of intravenous thrombolysis in acute ischemic stroke patients with saccular intracranial aneurysms

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Manoj K MittalAlejandro A Rabinstein

Abstract

It is not known if the presence of unruptured intracranial aneurysms can increase the risk of hemorrhage after thrombolysis for acute ischemic stroke. The goal of our study was to evaluate the risk of hemorrhage after intravenous tissue plasminogen activator in acute stroke patients with intracranial aneurysms. This is a retrospective analysis of consecutive cases of patients with acute ischemic stroke who were treated with intravenous tissue plasminogen activator at Mayo Clinic between March 2002 and June 2011 and who were evaluated with invasive or noninvasive intracranial angiography. Univariate analyses were performed with the t, Chi-square, and Fisher exact tests where appropriate. Intracranial angiograms were performed in 105 patients (85 magnetic resonance angiography, 19 computed tomography angiography, and 1 catheter arteriography). The mean age of the patients was 69 ± 14 years. The mean National Institutes of Health Stroke Scale score at admission was 8 ± 5. A total of 12 incidental saccular aneurysms were found in 10 (9.5%) patients, and all 10 of these patients were white. There were no subarachnoid hemorrhages during the hospital stay in any patient with or without intracranial aneurysm. The rates of symptomatic i...Continue Reading

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Citations

Sep 18, 2015·International Journal of Stroke : Official Journal of the International Stroke Society·Ashkan MowlaL N Hopkins
Dec 30, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Julien Francisco Zaldivar-JolissaintRoy Thomas Daniel
Dec 20, 2014·Case Reports in Neurological Medicine·Diana Briosa E GalaJoão Alcântara
Aug 20, 2015·The Neurohospitalist·Jennifer E Fugate, Alejandro A Rabinstein
Jun 24, 2017·Expert Review of Neurotherapeutics·Georgios TsivgoulisAndrei V Alexandrov
Mar 16, 2018·International Journal of Stroke : Official Journal of the International Stroke Society·Yuji ShonoTakanari Kitazono
Dec 24, 2015·Stroke; a Journal of Cerebral Circulation·Bart M DemaerschalkUNKNOWN American Heart Association Stroke Council and Council on Epidemiology and Prevention
Oct 26, 2018·Stroke; a Journal of Cerebral Circulation·Monica Lin ChenHooman Kamel
Nov 6, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·Robert HurfordUNKNOWN Oxford Vascular Study Phenotyped Cohort

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