Safety of Liraglutide in Type 2 Diabetes and Chronic Kidney Disease.

Clinical Journal of the American Society of Nephrology : CJASN
Johannes F E MannLEADER Trial Investigators

Abstract

The glucagon-like peptide-1 receptor agonist liraglutide demonstrated cardiovascular and kidney benefits in the LEADER trial, particularly in participants with CKD. This post hoc analysis evaluated the safety of liraglutide treatment in patients with CKD in LEADER. Overall, 9340 patients were randomized to liraglutide or placebo, both in addition to standard of care. Of those, 2158 patients had CKD versus 7182 without CKD (defined as eGFR <60 versus ≥60 ml/min per 1.73 m2, respectively); 966 patients had macroalbuminuria and 2456 had microalbuminuria (urine albumin-creatinine ratio >300 mg/g and ≥30 to ≤300 mg/g, respectively). At baseline, the mean eGFR in patients with CKD was 46±11 ml/min per 1.73 m2 versus 91±22 ml/min per 1.73 m2 in those without CKD. Time to first event within event groups was analyzed using Cox regression with treatment group, baseline eGFR group, or baseline albuminuria group as fixed factors. Overall, serious adverse events were more frequently recorded in patients with CKD compared with those without CKD (59% versus 50%; interaction P=0.11); however, they occurred to the same extent in those on liraglutide versus placebo. Similarly, no interaction of adverse events with randomized therapy was observed...Continue Reading

References

Jun 9, 2006·The New England Journal of Medicine·Lesley A StevensAndrew S Levey
Apr 12, 2007·British Journal of Clinical Pharmacology·Helle LinnebjergRobert Lins
Aug 6, 2008·Expert Opinion on Drug Metabolism & Toxicology·Albert W Dreisbach, Juan J L Lertora
May 9, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Maureen F MoenJeffrey C Fink
Dec 17, 2009·British Journal of Clinical Pharmacology·Lisbeth V JacobsenMilan Zdravkovic
Apr 25, 2012·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Kleopatra Alexiadou, John Doupis
May 2, 2014·Advances in Chronic Kidney Disease·Ragnar Pálsson, Uptal D Patel
Apr 18, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Salvatore De CosmoUNKNOWN AMD-Annals Study Group
Apr 24, 2016·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·G PennoS Del Prato
Jun 14, 2016·The New England Journal of Medicine·Steven P MarsoUNKNOWN LEADER Trial Investigators
Jun 15, 2016·The New England Journal of Medicine·Christoph WannerUNKNOWN EMPA-REG OUTCOME Investigators
Jul 7, 2016·Clinical Pharmacology : Advances and Applications·Melanie DaviesKamlesh Khunti
Jul 30, 2016·Diabetology & Metabolic Syndrome·Roberto Pecoits-FilhoSergio Vencio
Oct 19, 2016·Diabetes, Obesity & Metabolism·Bernt J von ScholtenPeter Rossing
Jun 13, 2017·The New England Journal of Medicine·Bruce NealUNKNOWN CANVAS Program Collaborative Group
Aug 9, 2017·Kidney Diseases·Bancha Satirapoj
Aug 31, 2017·The New England Journal of Medicine·Johannes F E MannUNKNOWN LEADER Steering Committee and Investigators
Sep 10, 2017·BMJ : British Medical Journal·Owen Dyer
Nov 6, 2018·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Bernard ZinmanUNKNOWN LEADER Publication Committee on behalf of the LEADER Trial Investigators
Apr 17, 2019·The New England Journal of Medicine·Vlado PerkovicUNKNOWN CREDENCE Trial Investigators

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Citations

Mar 10, 2020·Clinical Journal of the American Society of Nephrology : CJASN·David Z Cherney, Katherine R Tuttle
Sep 15, 2020·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Vikas S SridharDavid Z Cherney
Oct 20, 2020·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Kiran Chintam, Alex R Chang
Apr 28, 2021·Diabetes, Obesity & Metabolism·Richard SongPriya Sumithran

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