Safety of low-dose subcutaneous enoxaparin for the prevention of venous thromboembolism after primary intracerebral haemorrhage

Thrombosis Research
Sami TetriMatti Hillbom

Abstract

The risks and benefits of low molecular weight heparins (LMWH) for the prevention of deep-vein thrombosis (DVT) and pulmonary embolism (PE) after intracerebral haemorrhage (ICH) have not been assessed. The few studies on this subject have revealed conflicting results. We retrospectively evaluated whether subcutaneous enoxaparin (20 mg daily) reduced symptomatic venous complications or caused increased 3-month death rate. We included 407 patients who were admitted to a stroke unit and survived the first two days after onset of ICH. There were 232 patients who received anticoagulant treatment for the prevention of DVT and PE and 175 who did not. Despite the fact that the treated patients were in worse clinical condition at the start of the treatment, 3-month death rate was 19% among them compared to 21% among those not receiving anticoagulant therapy. Low-dose subcutaneous enoxaparin (20 mg once daily) induced a significant plasma anti-factor Xa activity 2-3 hours after administration (p=0.018). Haematoma enlargements (33%) occurred in 9% and 7% of the treated and untreated patients, whereas symptomatic venous thromboembolic complications were observed in 3% and 2%, respectively. We did not observe any increased mortality among I...Continue Reading

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References

May 1, 1991·Journal of Neurology, Neurosurgery, and Psychiatry·A BoeerH W Prange
Feb 24, 1998·Stroke; a Journal of Cerebral Circulation·K C JohnstonE C Haley
Jan 4, 2001·Stroke; a Journal of Cerebral Circulation·J KellyB J Hunt
Sep 28, 2005·Neurology·K LacutUNKNOWN VICTORIAh (Venous Intermittent Compression and Thrombosis Occurrence Related to Intra-cerebral Acute hemorrhage) Investigato
Dec 20, 2005·The American Journal of Cardiology·Elias SkafRonald E Olson
Jan 16, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C AndréM M Fukujima

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Citations

Jun 1, 2012·Case Reports in Medicine·Charles M KwobahAbraham M Siika
Sep 19, 2012·Interdisciplinary Perspectives on Infectious Diseases·Ramesh Marne Bhat, Chaitra Prakash
Dec 18, 2013·British Journal of Anaesthesia·H T BenzonR O Bonow
Dec 17, 2011·Lancet Neurology·Joyce S Balami, Alastair M Buchan
Jul 28, 2010·PM & R : the Journal of Injury, Function, and Rehabilitation·Brian M KellyThomas W Wakefield
Aug 4, 2009·Thrombosis Research·Walter AgenoUNKNOWN Italian Society for Haemostasis and Thrombosis
Sep 1, 2015·Journal of the Neurological Sciences·Zhou ZengJie Zhang
Jan 22, 2013·Clinical Neurology and Neurosurgery·Pekka LöppönenMatti Hillbom
Apr 25, 2015·Neurologic Clinics·Allyson Zazulia
Jul 8, 2011·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Thalia S Field, Michael D Hill
Apr 22, 2011·Journal of Pharmacy Practice·Dennis ParkerXi Liu-DeRyke
May 23, 2012·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Luca MasottiWalter Ageno
May 26, 2017·The Cochrane Database of Systematic Reviews·Luke A PerryRustam Al-Shahi Salman
Jan 13, 2015·Stroke; a Journal of Cerebral Circulation·Shyam PrabhakaranDawn O Kleindorfer
Dec 25, 2009·Neurocritical Care·Ahmed M RaslanAnish Bhardwaj
Feb 1, 2011·Continuum : Lifelong Learning in Neurology·Michael J Schneck, José Biller
Feb 25, 2020·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Ping ZhangFurong Wang
Nov 17, 2010·Neurocritical Care·Adnan I Qureshi
Sep 7, 2016·Journal of Neuro-oncology·Nasser AlshehriTimothy R Smith
Nov 12, 2020·International Journal of Stroke : Official Journal of the International Stroke Society·Ashkan ShoamaneshLaura C Gioia
Dec 1, 2020·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Mohammed F KananehMatthew D Vibbert
Dec 30, 2009·Current Opinion in Neurology·George NtaiosPatrik Michel

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