Safety of non-insulin glucose-lowering drugs in pregnant women with pre-gestational diabetes: A cohort study

Diabetes, Obesity & Metabolism
Lucía Cea-SorianoSonia Hernández-Díaz

Abstract

To evaluate the association between use of non-insulin antidiabetics in early pregnancy and the risk of miscarriages, stillbirths and major structural malformations. A cohort of 1511 pregnant women with pre-gestational diabetes linked to live births was identified using electronic medical records from The Health Improvement Network (THIN) for the period 1995 to 2012. Information on prescriptions, foetal outcomes and potential confounders was ascertained from both codes and free text in the THIN database. Odds ratios (OR) and 95% confidence intervals (CI) of adverse foetal outcomes in women treated with non-insulin antidiabetics during the first trimester compared to those on insulin were estimated using logistic regression to adjust for type of diabetes, glycaemic control and other maternal characteristics. Among 311 pregnant women on non-insulin antidiabetics, 21.9% had a miscarriage and 1.6% a stillbirth; 1.9% of live births had major malformations. The corresponding frequencies for the 883 women on insulin were 13.3%, 1.7% and 9.6%. Insulin users more often had type 1 diabetes and poor glycaemic control. Compared to women with type 1 diabetes, those with type 2 diabetes had a higher risk of miscarriages (20.5% vs 12.8%) but ...Continue Reading

References

May 8, 2002·Diabetes/metabolism Research and Reviews·Edith W M T ter BraakGerard H A Visser
Nov 9, 2002·Obstetrics and Gynecology·Jeanne S SheffieldKenneth J Leveno
Dec 21, 2004·Informatics in Primary Care·Alison BourkeMichael Robinson
May 25, 2005·Diabetic Medicine : a Journal of the British Diabetic Association·J W WyattUNKNOWN IONS study group
Aug 31, 2006·Pharmacoepidemiology and Drug Safety·Sonia Hernández-Díaz
Oct 27, 2006·Pharmacoepidemiology and Drug Safety·James D LewisBrian L Strom
Sep 19, 2007·European Journal of Obstetrics, Gynecology, and Reproductive Biology·R A GandhiI Idris
Oct 2, 2007·American Journal of Obstetrics and Gynecology·Moshe HodUNKNOWN Insulin Aspart Pregnancy Study Group
May 9, 2008·The New England Journal of Medicine·Janet A RowanUNKNOWN MiG Trial Investigators
Aug 5, 2008·American Journal of Obstetrics and Gynecology·Adolfo CorreaE Albert Reece
Oct 14, 2009·Pharmacoepidemiology and Drug Safety·Scott DevineAndrew Olshan
Jan 14, 2010·Diabetes Care·Sandra S AlbrechtWilliam M Callaghan
Mar 6, 2010·Congenital Anomalies·Deeke YolmoS Gopalakrishnan
Aug 27, 2010·American Journal of Obstetrics and Gynecology·Jaya Saxena DhulkotiaTom Farrell
Dec 15, 2011·JAMA : the Journal of the American Medical Association·UNKNOWN Stillbirth Collaborative Research Network Writing Group
Dec 15, 2011·Current Diabetes Reports·E Albert Reece
Apr 12, 2012·The Journal of Clinical Endocrinology and Metabolism·Catherine C BeauharnaisDeborah J Wexler
Jul 3, 2013·Pharmacoepidemiology and Drug Safety·Lucia Cea-SorianoSonia Hernández-Díaz
May 28, 2014·Human Reproduction Update·Matteo CassinaMaurizio Clementi
Nov 24, 2016·International Journal of Health Services : Planning, Administration, Evaluation·Vicente Navarro

❮ Previous
Next ❯

Citations

May 29, 2018·Diabetes, Obesity & Metabolism·Katrien BenhalimaChantal Mathieu
Nov 22, 2018·Obstetrics and Gynecology·UNKNOWN American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Obstetrics
Dec 12, 2020·Clinical Obstetrics and Gynecology·Lindsay Maggio

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Related Papers

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Päivi KekäläinenTiina Laatikainen
© 2022 Meta ULC. All rights reserved