Safety of Oral Food Challenges in Early Life

Children
Katherine Anagnostou

Abstract

Oral food challenges are becoming more frequent in the allergy clinic due to an increased demand related to early food introduction in infants. We examined the safety of oral food challenges in 18 high-risk infants with prior allergic reactions, as well as infants with no known exposure to the food, presenting consecutively in a dedicated food allergy clinic for an oral food challenge. Foods challenged included peanut, tree nuts, sesame, baked egg, baked milk, and soy. A total of 17/18 (94%) infants had a negative challenge. Only 1/18 (6%) had a positive challenge, and in this case, symptoms were mild and limited to the skin. Our results suggest that food challenges in infants and young children up to the age of 2 years are safe with symptoms limited to the skin when reactions occur. In our cohort, the large majority of food challenges were negative, with most infants being sensitized rather than allergic to the food. Larger studies are needed to confirm this finding.

References

Jan 5, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·S H SichererA Muñoz-Furlong
Oct 15, 2008·The Journal of Allergy and Clinical Immunology·Heather Lemon-MuléAnna Nowak-Wegrzyn
Jan 17, 2012·Immunology and Allergy Clinics of North America·Katrina J Allen, Jennifer J Koplin
Dec 3, 2014·The Journal of Allergy and Clinical Immunology·F Estelle R Simons, Hugh A Sampson
Jan 13, 2015·The Journal of Allergy and Clinical Immunology. in Practice·Stephanie A LeonardAnna Nowak-Węgrzyn
Feb 24, 2015·The New England Journal of Medicine·George Du ToitUNKNOWN LEAP Study Team
Nov 14, 2016·The Journal of Allergy and Clinical Immunology. in Practice·J Andrew BirdMichael C Young
Sep 21, 2017·The New England Journal of Medicine·Stacie M Jones, A Wesley Burks

❮ Previous
Next ❯

Citations

Jul 14, 2019·The Journal of Allergy and Clinical Immunology. in Practice·Elaine HsuEdmond S Chan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

The Journal of Allergy and Clinical Immunology
Hugh A Sampson
Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
Paul J TurnerDianne Campbell
© 2022 Meta ULC. All rights reserved