Safety of oseltamivir compared with the adamantanes in children less than 12 months of age.

The Pediatric Infectious Disease Journal
David W KimberlinNIAID Collaborative Antiviral Study Group

Abstract

When oseltamivir is administered in extremely high doses (500-1000 mg/kg) to young juvenile rats, central nervous system toxicity and death occurred in some animals. Mortality was not observed in older juvenile rats, suggesting a possible relationship between neurotoxicity and an immature blood-brain barrier. To assess potential neurologic adverse effects of oseltamivir use in infants, a retrospective chart review was performed in infants less than 12 months of age who received oseltamivir, amantadine, or rimantadine. The primary objective was to describe the frequency of neurologic adverse events among children less than 12 months of age who received oseltamivir compared with those receiving adamantanes. Medical record databases, emergency department databases, and/or pharmacy records at 15 medical centers were searched to identify patients. Of the 180 infants identified as having received antiviral therapy, 115 (64%) received oseltamivir, 37 (20%) received amantadine, and 28 (16%) received rimantadine. The median dose of oseltamivir was 2.0 mg/kg/dose in 3- to 5-month-old and 2.2 mg/kg/dose in 9- to 12-month-old infants. The maximum dose administered was 7.0 mg/kg/dose. There were no statistically significant differences in t...Continue Reading

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Citations

Jan 19, 2012·The Pediatric Infectious Disease Journal·Shikha GargLyn Finelli
Jul 6, 2010·Current Opinion in Pediatrics·Firoza Faruqui, Deepa Mukundan
Apr 12, 2012·Clinical Microbiology Reviews·Vincent C C ChengKwok-Yung Yuen
Aug 31, 2010·Paediatric Drugs·Steven M Smith, John G Gums
May 1, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Shikha GargAlicia M Fry
Jan 15, 2011·Journal of Perinatology : Official Journal of the California Perinatal Association·P S PannarajD Akan
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Oct 22, 2014·Pharmacoepidemiology and Drug Safety·Barbara A RathMartina Wollenhaupt
Mar 31, 2011·Pharmacoepidemiology and Drug Safety·Barbara DonnerViswanathan Niranjan
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Apr 14, 2012·Scandinavian Journal of Infectious Diseases·Ichiro MoriokaUNKNOWN Committee for the Control and Prevention of Influenza of the Japan Pediatric Society
Apr 5, 2011·American Journal of Obstetrics and Gynecology·Laura G GreerJeanne S Sheffield
Aug 28, 2012·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Barbara RathBrunhilde Schweiger
Sep 7, 2016·Clinical and Translational Medicine·Rashmi DixitRobert Booy
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Aug 2, 2017·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Muhammet Sukru PaksuHaydar Ali Tasdemir

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