Safety of preoperative ibuprofen in pediatric tonsillectomy

The Laryngoscope
Alexander MichaelGlenn Isaacson

Abstract

Oral ibuprofen is believed to be safe and effective after pediatric adenotonsillectomy. There has been little study of its use as a preoperative analgesic. We attempt to document its safety in this setting. Individual case control study. Children who underwent tonsillectomy or adenotonsillectomy from January 2013 to December 2015 did not receive preoperative ibuprofen. Those who underwent tonsillectomy or adenotonsillectomy from January 2016 to December 2017 received oral ibuprofen 7 mg/kg preoperatively. Pre- and postoperative records were reviewed. Intraoperative bleeding > 50 mL or early postoperative bleeding requiring surgical control were outcome measures. Delayed bleeding events were also recorded. A total of 217 children met inclusion criteria. Of those, 112 patients did not receive preoperative ibuprofen, and 105 patients did receive preoperative ibuprofen. Mean age was 8.7 years (range: 1-18) in the control/non-ibuprofen cohort and 8.3 years (range: 1-18) in the ibuprofen cohort. No child experienced significant intraoperative or early postoperative bleeding in the non-ibuprofen (95% confidence interval [CI] 0-0.027) or in the ibuprofen cohort (95% CI 0- 0.029). Delayed bleeding rates were similar in both groups. In t...Continue Reading

References

Mar 1, 1992·Journal of Clinical Pharmacology·R D BrownK M Bertrand
Aug 1, 1987·International Journal of Oral and Maxillofacial Surgery·C M HillN Pickvance
Oct 22, 2003·Archives of Otolaryngology--head & Neck Surgery·Srinivasan KrishnaSandra Y Lin
Dec 13, 2003·Archives of Disease in Childhood·I ArranzE Ripoll
Apr 6, 2005·Annals of Internal Medicine·Neil A GoldenbergMarilyn J Manco-Johnson
Nov 16, 2005·The Annals of Otology, Rhinology, and Laryngology·Glenn Isaacson
Aug 19, 2008·Wiener klinische Wochenschrift·Christoph ArnoldnerBoban M Erovic
Nov 6, 2008·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·J Grainger, N Saravanappa
Apr 22, 2011·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Reginald F BaughUNKNOWN American Academy of Otolaryngology-Head and Neck Surgery Foundation
Nov 24, 2011·The Laryngoscope·Stephanie SarnyHeinz Stammberger
Jan 25, 2013·The Annals of Otology, Rhinology, and Laryngology·Stephanie SarnyHeinz Stammberger
Dec 18, 2013·The Laryngoscope·Dylan K Chan, Sanjay R Parikh
Jan 22, 2014·The American Journal of Nursing·Kimberly A Sutters, Glenn Isaacson
May 29, 2014·The Laryngoscope·Robert F YellonPeter J Davis
Sep 13, 2014·Otolaryngologic Clinics of North America·Glenn Isaacson
Dec 18, 2014·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·A-C Hessén SödermanJ Stalfors
Jan 28, 2015·Pediatrics·Lauren E KellyGideon Koren
Mar 10, 2015·Military Medicine·Wenjun Z MartiniMichael A Dubick
Sep 4, 2015·Acta ortopedica brasileira·Enrico GiulianiAlberto Barbieri
Mar 29, 2016·Plastic and Reconstructive Surgery·Brian P KelleyJeffrey H Kozlow
May 5, 2017·JAMA Otolaryngology-- Head & Neck Surgery·Pamela A MuddJorge A Gálvez
Dec 2, 2017·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Farrel J Buchinsky, Neil K Chadha

❮ Previous
Next ❯

Citations

Mar 6, 2019·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Khanh K NguyenJared C Inman
Aug 21, 2020·Anaesthesia and Intensive Care·Natalie AklDavid Sommerfield

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
E J ReimerP M Merrick
Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Christopher A RobertsMichele M Carr
Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Adva BuziLisa Elden
© 2022 Meta ULC. All rights reserved