Safety of Propofol versus Nonpropofol-Based Sedation in Children Undergoing Gastrointestinal Endoscopy: A Systematic Review and Meta-Analysis

Gastroenterology Research and Practice
Neeraj NarulaArianne Buchan

Abstract

The majority of children who undergo gastrointestinal (GI) endoscopy require anesthesia or procedural sedation for comfort, cooperation, and procedure efficiency. The safety profile of propofol is not well established in children but has been studied in the literature. The aim of this study is to evaluate and compare the safety of propofol-only sedation for GI endoscopy procedures to other anesthetic regimes in the pediatric population. A search was conducted in the MEDLINE, Embase, and Cochrane Library databases. Randomized clinical trials and prospective cohorts were included in the study. No significant difference was noted in total complications between the two cohorts with a pooled OR of 1.31 (95% CI: 0.57-3.04, chi2 = 0.053, I2 = 54.31%). The pooled rate of complications in the studies was 23.4% for those receiving propofol only and 18.2% for those receiving other anesthetic regimens. Sensitivity analysis was performed removing a study with a very different control comparison compared to the rest of the studies included. Once excluded, there was minimal heterogeneity in the remaining studies and a significant difference in overall complications was detected, with more complications seen in the propofol-only group compared...Continue Reading

References

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Citations

Oct 29, 2019·Current Cancer Drug Targets·Milad AshrafizadehSaeed Samarghandian
Dec 17, 2019·World Journal of Gastrointestinal Endoscopy·Aureo Augusto de Almeida DelgadoEduardo Guimarães Hourneaux de Moura
Jan 17, 2021·Journal of Clinical Medicine·Pasquale CapaccioLorenzo Pignataro
Mar 12, 2021·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Sara IsoldiSalvatore Oliva
Aug 31, 2021·Frontiers in Pediatrics·Kayla T HartjesJenifer R Lightdale

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Methods Mentioned

BETA
sedation

Software Mentioned

Cochrane Risk
OVID
Comprehensive Meta - Analysis
Prisma

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