Safety of rapid-rate transcranial magnetic stimulation: heart rate and blood pressure changes

Electroencephalography and Clinical Neurophysiology
A FoersterD Claus

Abstract

We examined the influence of rapid-rate transcranial magnetic stimulation on heart rate and blood pressure in 13 healthy volunteers. In a first series three different cortical magnetic stimuli were applied: over C3, C4 and Fz (10/20 system), in a second series additionally over Pz. We also used a stimulus over the brachial plexus and a sham stimulus. Five stimuli of each location were applied with a Cadwell high speed magnetic stimulator using a focal point circular coil. Stimulus train duration was 500 ms, stimulus frequency 20 Hz. Stimulus strength was 70-90% of maximum stimulator output, 20% of maximum stimulator output above subjects' individual motor threshold. The subjects assessed stimulus inconvenience immediately after stimulation. ECG and blood pressure (Finapres) were recorded continuously during the 1 h test. In all subjects there was a clearly marked autonomic response with heart rate acceleration and decrease in blood pressure after all stimuli. There was no difference in responses between cortical stimuli. Blood pressure decrease after sham stimulation was significantly smaller than after cortical stimulation, it was more marked after brachial plexus stimulation. Autonomic reaction correlates well with subjective...Continue Reading

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Citations

Jan 4, 2001·Journal of the Neurological Sciences·L NiehausB Meyer
Nov 19, 2002·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Richard A L MacdonellSamuel F Berkovic
Dec 14, 2011·Neurophysiologie clinique = Clinical neurophysiology·J-P LefaucheurL Garcia-Larrea
Oct 29, 2011·Brain Stimulation·Setsu Nakatani-EnomotoYoshikazu Ugawa
Jun 18, 2010·Headache·David W DodickSheena K Aurora
Apr 6, 2016·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Simone RossiMonica Ulivelli
Oct 17, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Simone RossiUNKNOWN Safety of TMS Consensus Group
May 21, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Pedro SchestatskyFelipe Fregni
Mar 18, 2000·IEEE Transactions on Bio-medical Engineering·J RuohonenR J Ilmoniemi
Apr 7, 2021·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Yuki MatsudaShinsuke Kito

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