Safety of regadenoson as a pharmacologic stress agent for myocardial perfusion imaging in chronic kidney disease patients not on hemodialysis.

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
Gurunanthan PalaniKarthik Ananthasubramaniam

Abstract

Pharmacokinetic studies suggest delayed clearance of Regadenoson (REG), a new selective A2A receptor agonist in chronic kidney disease (CKD). The safety of REG in large series of CKD patients in daily clinical practice remains unstudied. Retrospective study of patients with eGFR < 60 mL/min (n = 411, Grp 1, CKD) were compared to patients with eGFR ≥ 60 mL/min (n = 638, Grp 2, Control) undergoing REG-SPECT from Jan to Nov 2009. Patient demographics, REG-SPECT data, side effects, and arrhythmia occurrences were evaluated. No major adverse events were noted immediately after REG-SPECT or at 1 week of follow-up. There were no differences in any arrhythmias in between the two groups (Grp 1, 47.2% vs Grp 2, 42.9%, P = ns). Ninety-nine percent of arrhythmias in CKD patients were PACs or PVCs. Transient junctional rhythm was observed in one CKD patient. There were no occurrences of second degree or higher degree AV block. Grp 1 had a blunted heart rate response (16.6 ± 16.1 vs 24.9 ± 20.3 bpm, P ≤ .001) and greater systolic blood pressure drop response (-7.4 ± 21.1 vs -1.4 ± 20.9 mm Hg, P ≤ .001) compared to Grp 2. Transient headache was more in Grp 2 (15.8% vs 22.6%, P ≤ .007). Aminophylline use to ward-off the side effects was compar...Continue Reading

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Citations

Feb 14, 2012·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·E Gordon DepueyL Samuel Wann
Dec 15, 2012·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Rami DoukkyRaysa Morales Demori
Dec 12, 2012·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ami E IskandrianJaekyeong Heo
Feb 23, 2013·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Rafael CabreraKarthik Ananthasubramaniam
Jun 22, 2012·Journal of Postgraduate Medicine·G M BengalorkarT N Kumar
Jan 24, 2014·European Heart Journal Cardiovascular Imaging·Kim-Lien NguyenAndrew E Arai
Apr 5, 2014·European Heart Journal Cardiovascular Imaging·Sabha BhattiKarthik Ananthasubramaniam
Aug 12, 2014·International Journal of Cardiology·Vikram Agarwal, E Gordon DePuey
Dec 8, 2015·Future Cardiology·Eliana Reyes
Dec 17, 2014·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Maria Octavia RangelRami Doukky
Feb 26, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Milena J HenzlovaHein J Verberne
Sep 17, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Katherine N GharibianBruce A Mueller
Oct 19, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Efstathia AndrikopoulouFadi G Hage
May 31, 2012·Cardiology in Review·Gurunanthan Palani, Karthikeyan Ananthasubramaniam
Mar 24, 2015·Journal of Cardiovascular Medicine·Andrea Igoren GuaricciGianluca Pontone
Jul 8, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ahmed A KolkailahRami Doukky
Jan 13, 2015·Methodist DeBakey Cardiovascular Journal·John J MahmarianFaisal Nabi
Jun 28, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Aviral VijRami Doukky
Aug 16, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ankur Gupta, Navkaranbir S Bajaj
Oct 18, 2019·Frontiers in Pharmacology·Peter BoknikJoachim Neumann
May 29, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Talal AsifSaurabh Malhotra
Feb 13, 2021·Frontiers in Pharmacology·P BoknikU Gergs

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