Safety of selective cyclooxygenase-2 inhibitors in inflammatory bowel disease

The American Journal of Gastroenterology
Uma MahadevanWilliam J Sandborn

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) are relatively contraindicated in patients with inflammatory bowel disease (IBD) for fear of disease aggravation. Cyclooxygenase-2 inhibitors have fewer GI side effects than traditional NSAIDs in unselected patients. We report the safety of these agents in patients with IBD. Patients with Crohn's disease, ulcerative colitis, or pouchitis who used celecoxib or rofecoxib were identified from computerized prescription records. A retrospective chart review was conducted. Concomitant medications, past NSAID use, indication for cyclooxygenase-2 inhibitor, dose, and duration were obtained. IBD disease activity before cyclooxygenase-2 inhibitor use was graded using a modified disease activity index. Change in disease activity was graded as improved, no change, or worsened. Patients were contacted to provide data not found in the charts. The proportion of patients receiving cyclooxygenase-2 inhibitors who experienced exacerbation of IBD was determined. Eleven patients were treated with celecoxib (median dose = 200 mg/day), and 16 patients were treated with rofecoxib (median dose = 25 mg/day). Median duration of therapy was 9 months (range = 1 wk-22 months). The drug was beneficial in 14 pati...Continue Reading

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Related Concepts

Celebrex
Refecoxib
Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase), human
Ulcerative Colitis
IIeocolitis
Intestines
Alloenzymes
Lactones
Cell Surface Proteins
Prostaglandin-Endoperoxide Synthase

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