Safety of TeaCrine®, a non-habituating, naturally-occurring purine alkaloid over eight weeks of continuous use

Journal of the International Society of Sports Nutrition
Lem TaylorColin Wilborn

Abstract

Theacrine (1,3,7,9-tetramethyluric acid) is a purine alkaloid found in certain coffee (Coffea) species, fruits (Cupuacu [Theobroma grandiflorum]), and tea (Camellia assamica, var. kucha) that has anti-inflammatory, analgesic, and neuro-locomotor properties. Recent preliminary research has also reported increased feelings of energy, reduced fatigue, and strong effects on improving focus, concentration, and motivation to exercise. The purpose of this study was to examine the safety and non-habituating effects of TeaCrine®, a nature-identical, chemically equivalent bioactive version of theacrine. Sixty healthy men (mean ± SD age, height, weight: 22.9 ± 4.7 years, 183.5 ± 9.2 cm, 86.5 ± 13.7 kg) and women (22.3 ± 4.5 years, 165.2 ± 12.3 cm, 69.0 ± 17.4 kg) were placed into one of three groups: placebo (PLA, n = 20), 200 mg TeaCrine® (LD, n = 19) or 300 mg Teacrine® (HD, n = 21) and ingested their respective supplement once daily for 8 weeks. Primary outcomes were fasting clinical safety markers (heart rate, blood pressure, lipid profiles, hematologic blood counts, biomarkers of liver/kidney/immune function) and energy, focus, concentration, anxiety, motivation to exercise, and POMS measured prior to daily dosing to ascertain potent...Continue Reading

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Citations

Sep 17, 2016·Journal of Toxicology·Amy ClewellIlona Pasics Szakonyiné
Mar 14, 2018·Journal of Dietary Supplements·Marcos DaouAdam M Gonzalez
Apr 20, 2019·Journal of the International Society of Sports Nutrition·Marissa L BelloShawn M Arent
Oct 30, 2019·Journal of the International Society of Sports Nutrition·Kyle R CesareoMichael J Ormsbee
Sep 7, 2017·Journal of Caffeine Research·Hui HeCharles R Yates
Jan 9, 2020·Journal of Toxicology·Timothy S MurbachIlona Pasics Szakonyiné
Jan 5, 2021·Frontiers in Nutrition·Yue-Yue ShengXin-Qiang Zheng

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Methods Mentioned

BETA
blood collection

Software Mentioned

SPSS

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