Abstract
Stromal vascular fraction (SVF) therapy has been performed over the past six years to treat 421 patients by our group in five clinical centers. Autologous SVF, which is a substance containing stem cells, was isolated from lipoaspirate, mixed with platelet-rich plasma (PRP), and administered to patients with degenerative diseases, autoimmune diseases, trauma, aging, and other diseases with unknown etiology. This study aimed to determine the safety of SVF and PRP that were given through infusion, spinal, and intra-articular injection. The lipoaspirate was treated with a tissue-dissociating enzyme, and then, through centrifugation, SVF was isolated. In addition, blood was drawn from each patient, and PRP was isolated. Autologous PRP and SVF were administered to all subjects by intravenous (IV) injection. A minority group within the population received an additional spinal or intra-articular injection. The type of intervention was determined by each disease evaluation. The cell doses and adverse events for each patient were documented and analyzed. Cell dose that was considered to be safe was less than 10 billion SVF cells in 250 cc of normal saline, for IV injection, and less than 1 billion SVF, for intra-articular and spinal inje...Continue Reading
References
Dec 12, 2002·Molecular Biology of the Cell·Patricia A ZukMarc H Hedrick
Apr 16, 2004·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Robert E Marx
May 13, 2005·Archives of Dermatological Research·Hekla SigmundsdottirHelgi Valdimarsson
Jul 8, 2005·Cell and Tissue Research·Akiko YokoyamaTakeshi Muneta
Mar 25, 2006·Journal of Cellular Physiology·Kotaro YoshimuraKoichi Gonda
Mar 28, 2007·Annals of Neurology·Ezio GerdoniAntonio Uccelli
Jun 19, 2008·Cell and Tissue Research·Hideyuki KogaIchiro Sekiya
Apr 28, 2009·Journal of Translational Medicine·Neil H RiordanBoris Minev
Feb 23, 2010·Experimental Cell Research·S GarciaR de la Fuente
Feb 5, 2011·Retina·Rubens C SiqueiraRodrigo Jorge
Feb 10, 2011·Stem Cells and Development·Jeong Chan RaEuna Kwon
Jan 28, 2012·International Archives of Medicine·Eranda C RatnayakeBandula C Wijesiriwardena
Jul 19, 2013·The Korean Journal of Internal Medicine·Nayoun Kim, Seok-Goo Cho
Jan 9, 2014·Journal of Translational Medicine·Mahmood S ChoudheryDavid T Harris
Aug 8, 2015·Oxidative Medicine and Cellular Longevity·Katarzyna KornickaAgnieszka Śmieszek
Feb 11, 2016·BMC Musculoskeletal Disorders·Kade L PatersonDan Bates
Mar 5, 2016·Stem Cells International·Monika MarędziakBrandon Michael Henry
Jan 1, 2013·Journal of Medical Engineering·Phuc Van PhamNgoc Kim Phan
May 27, 2016·PloS One·Sophie DomergueDanièle Noël
Nov 9, 2016·PloS One·Yong-Beom ParkHan-Jun Lee
Mar 11, 2017·Journal of Orthopaedic Surgery and Research·Andy GoldbergRazi Zaidi
Jul 21, 2017·Journal of Clinical Medicine Research·Kristin ComellaRuben Corral Moreno
Oct 19, 2017·Journal of Clinical Medicine Research·Kristin ComellaWalter P Drake
Dec 15, 2017·BioMed Research International·Dou HuangCharbel Abi Khalil
Mar 6, 2018·Journal of Cosmetic Dermatology·Mohammad-Reza Mahmoudian-SaniMassoud Saidijam
Apr 11, 2018·Plastic and Reconstructive Surgery. Global Open·Joshua LuckAfshin Mosahebi
Apr 15, 2018·Thorax·Winifred BroekmanPieter S Hiemstra
May 17, 2018·PloS One·Oscar FernándezUNKNOWN Research Group Study EudraCT 2008-004015-35
May 19, 2017·Regenerative Therapy·Naomasa YokotaHideto Kaneshima
Oct 30, 2018·Journal of Cellular and Molecular Medicine·Katarzyna KornickaKrzysztof Marycz
Dec 6, 2019·Stem Cell Research & Therapy·Imam RosadiAnggraini Barlian
Feb 6, 2020·Cells·Greet MerckxAnnelies Bronckaers
Feb 11, 2020·Stem Cell Investigation· KarinaJeanne Adiwinata Pawitan