Hypertension is relatively uncommon in children and few children receive antihypertensive medications. This article reviews the safety of calcium channel blockers, angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists in children with hypertension. While the newer antihypertensive agents appear to be well-tolerated by children, further studies are needed to determine the safety profile across the developmental continuum, with chronic dosing and in children with complex hypertension.
Prevalence of "significant" hypertension in junior high school-aged children: the Children and Adolescent Blood Pressure Program
Antihypertensive effect and elimination kinetics of captopril in hypertensive children with renal disease
Effective use of captopril (angiotensin I-converting enzyme inhibitor) in severe childhood hypertension
Telangiectasia and gingival hyperplasia as side-effects of amlodipine (Norvasc) in a 3-year-old girl
Congenital anomalies of the kidney and urinary tract--role of the loss of function mutation in the pluripotent angiotensin type 2 receptor gene
Pediatric hypertension: diagnosis, evaluation, management, and treatment for the primary care physician
Assessment of the use of angiotensin receptor blockers in major European markets among paediatric population for treating essential hypertension
Antihypertensive Agents: Mechanisms of Action
Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.