Safety of vaccination against influenza A (H1N1) during pregnancy in the Netherlands: results on pregnancy outcomes and infant's health: cross-sectional linkage study

BJOG : an International Journal of Obstetrics and Gynaecology
Nicoline A T van der MaasHester E de Melker

Abstract

This study aims to assess the safety of Influenza A(H1N1), vaccination administered during the second and third trimester and containing MF59 and thiomersal (Focetria(®) ), measured by pregnancy outcomes and infant's health. Cross-sectional linkage study. A sample of pregnant women, eligible for prenatal screening, were invited to participate. Questionnaire data were linked with the Netherlands Perinatal Registry (n = 1920). Information on infant growth, development (n = 1739) and infection-related contacts with the general practitioner (GP) during the first year of life (n = 1671) was obtained. Multivariate logistic regression was used to assess the association between H1N1 vaccination and small-for-gestational-age infant, preterm delivery and a composite adverse outcome, i.e. low Apgar-score, neonatal intensive care unit admission, neonatal resuscitation or perinatal death. Influence of maternal vaccination on growth, development and GP infection-related contact rates were assessed using multivariate linear mixed modelling and multivariate negative binomial regression, respectively. Response rate was 21%. Though we found differences in characteristics between unvaccinated and vaccinated women, in the multivariate analyses no ...Continue Reading

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Citations

Aug 6, 2016·Human Vaccines & Immunotherapeutics·Isaac G SakalaNikolai Petrovsky
Jul 18, 2018·Human Vaccines & Immunotherapeutics·Eun-Ju Ko, Sang-Moo Kang
Nov 2, 2018·Human Vaccines & Immunotherapeutics·Michelle L GilesAllen Cheng
Feb 20, 2020·Acta Obstetricia Et Gynecologica Scandinavica·Joep C KortekaasEsteriek De Miranda
Oct 28, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Eleonora BrilloErsilia Buonomo
Jun 9, 2021·JAMA : the Journal of the American Medical Association·Azar MehrabadiDeshayne B Fell

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