Safety perspectives on presently considered drugs for the treatment of COVID-19.

British Journal of Pharmacology
Sophie L PenmanAmy E Chadwick

Abstract

Intense efforts are underway to evaluate potential therapeutic agents for the treatment of COVID-19. In order to respond quickly to the crisis, the repurposing of existing drugs is the primary pharmacological strategy. Despite the urgent clinical need for these therapies, it is imperative to consider potential safety issues. This is important due to the harm-benefit ratios that may be encountered when treating COVID-19, which can depend on the stage of the disease, when therapy is administered and underlying clinical factors in individual patients. Treatments are currently being trialled for a range of scenarios from prophylaxis (where benefit must greatly exceed risk) to severe life-threatening disease (where a degree of potential risk may be tolerated if it is exceeded by the potential benefit). In this perspective, we have reviewed some of the most widely researched repurposed agents in order to identify potential safety considerations using existing information in the context of COVID-19.

References

May 1, 1967·Toxicology and Applied Pharmacology·E W McChesneyR J Fabian
Jul 1, 1997·Clinical Therapeutics·M Weber
Jul 1, 1997·The Journal of Steroid Biochemistry and Molecular Biology·E S TomlinsonD J Back
Dec 31, 1998·Arthritis and Rheumatism·B BresnihanP Musikic
Mar 19, 2002·Antimicrobial Agents and Chemotherapy·Y FurutaK Shiraki
Apr 19, 2002·The Journal of Biological Chemistry·Jose A Sánchez-ChapulaMichael C Sanguinetti
May 3, 2003·Viral Immunology·Sol M Cancel Tirado, Kyoung-Jin Yoon
Jul 5, 2003·Clinical Pharmacology and Therapeutics·Bing-Bing YangJohn T Sullivan
Nov 1, 2003·The Lancet Infectious Diseases·Andrea SavarinoRoberto Cauda
Jan 2, 2004·Indian Journal of Pediatrics·Bonilla NayarNeena Malhotra
Mar 20, 2004·Emerging Infectious Diseases·Lisa E HensleyThomas W Geisbert
Apr 13, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Andrea SavarinoRoberto Cauda
Jun 7, 2005·Expert Opinion on Drug Safety·Martin Traebert, Berengere Dumotier
Jul 21, 2005·Clinical Pharmacokinetics·Domenic A SicaSiddhartha Ghosh
Aug 24, 2005·Virology Journal·Martin J VincentStuart T Nichol
Jan 4, 2006·Proceedings·C C Ogu, J L Maxa
Apr 1, 2006·Clinical Rheumatology·Vicente Giner GalvañJosep Redón
Jul 11, 2006·Drugs·Vicki Oldfield, Greg L Plosker
Feb 16, 2007·Tropical Medicine & International Health : TM & IH·Leopoldo VillegasFrançois Nosten
Nov 24, 2007·European Journal of Immunology·Jan KissMarko Salmi
Jan 25, 2008·Proceedings of the National Academy of Sciences of the United States of America·Aldo A Rodríguez-MenchacaJosé A Sánchez-Chapula
Mar 7, 2008·Cytokine & Growth Factor Reviews·Volker Thiel, Friedemann Weber
Apr 16, 2009·Clinical Microbiology Reviews·Edsel Maurice T Salvana, Robert A Salata
May 19, 2009·The Journal of Rheumatology·Marty Mertens, Jasvinder A Singh
Apr 7, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jordan S FridmanKris Vaddi
Feb 5, 2011·Ophthalmology·Michael F MarmorUNKNOWN American Academy of Ophthalmology
Jan 1, 2010·International Journal of Nephrology and Renovascular Disease·Elizabeth Ripley, Ari Hirsch
Sep 2, 2011·Rheumatology International·Christina KaiserBjörn Pilström
Aug 2, 2012·Nature Reviews. Drug Discovery·Charles A DinarelloJos W M van der Meer
Aug 2, 2012·Molecular Pharmacology·Daniela Ponce-BalbuenaJosé A Sánchez-Chapula

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Citations

Aug 29, 2020·Signal Transduction and Targeted Therapy·Yi ChenLiang Ouyang
Sep 14, 2021·Journal of Biomolecular Structure & Dynamics·Glaucio Monteiro FerreiraAntti Poso

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Methods Mentioned

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glycosylation
biopsy

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