Safety profile of conjugated linoleic acid in a 12-month trial in obese humans

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
L D WhighamR L Atkinson

Abstract

Conjugated linoleic acid (CLA) is marketed in numerous commercially available dietary supplements, but few studies have looked at the long-term safety of this product. The current study evaluated the safety of one CLA product (Clarinol) over a one-year period in obese humans who were generally healthy. This was a randomized, double-blind study consisting of three phases in which subjects were given 6 g/day of CLA or placebo. Phase 1 was a low calorie diet (13 kcal/kg desirable weight) for 12 weeks or until 10-20% of initial body weight was lost. In phase 2, from weeks 12 to 28, subjects were re-fed a diet providing 25-30 kcal/kg of desirable body weight. Phase 3 was open label, with subjects from both groups taking CLA from weeks 28 to 52. At biweekly visits, subjects completed a questionnaire evaluating side effects and adverse events. Blood was taken for assay of liver function, glucose, insulin, serum lipids, blood counts, and general chemistry. Overall, body composition did not differ between groups. Laboratory tests showed no adverse effects of CLA. Adverse events and side effects were less in the CLA group compared to placebo. We conclude that CLA as Clarinol is safe for use in obese humans for at least one year.

References

Dec 1, 1995·Medicine and Science in Sports and Exercise·M A McCroryP A Molé
Nov 1, 1995·Journal of Dairy Science·H LinT D Shultz
Feb 1, 1997·Lipids·M A Belury, A Kempa-Steczko
Apr 16, 1998·Biochemical and Biophysical Research Communications·K L HouseknechtM A Belury
Nov 4, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·L D WhighamR L Atkinson
Nov 25, 2000·The Journal of Nutritional Biochemistry·M YamasakiK Yamada
Dec 9, 2000·The Journal of Nutrition·H BlanksonO Gudmundsen
Jul 31, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·U RisérusB Vessby
Jul 31, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·J C Wells, N J Fuller
Sep 5, 2001·The Journal of Nutrition·J Bassaganya-RieraM J Wannemuehler
Mar 23, 2002·Lipids·Nicole MastersMichelle K McGuire
Sep 11, 2002·The Journal of Nutrition·Jean-Christophe BouthegourdJean-Charles Martin
Sep 18, 2002·Journal of Lipid Research·Lionel ClémentPhilippe Besnard
Dec 20, 2002·Obesity Research·Kimberly M HargraveClifton A Baile
Feb 6, 2003·Medicine and Science in Sports and Exercise·R Randall ClarkDale A Schoeller
May 29, 2003·The Journal of Nutrition·Nobuyo Tsuboyama-KasaokaOsamu Ezaki
Jun 25, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M M J W KamphuisM S Westerterp-Plantenga
Oct 18, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S O'Hagan, A Menzel
Apr 20, 2004·Obesity Research·Corinne Malpuech-BrugèreBernard Beaufrère
May 6, 2004·Medicine and Science in Sports and Exercise·Valerie EyjolfsonDavid J Dyck
May 26, 2004·The American Journal of Clinical Nutrition·Jean-Michel GaullierOla Gudmundsen
May 26, 2004·The American Journal of Clinical Nutrition·Marianne O'SheaInge C M Mohede

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Citations

May 9, 2009·European Journal of Nutrition·Ganesh V HaladeGabriel Fernandes
Jul 20, 2012·European Journal of Nutrition·Mario KratzStephan Guyenet
Mar 29, 2012·Critical Reviews in Food Science and Nutrition·Allison Dilzer, Yeonhwa Park
May 29, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Josep Bassaganya-Riera, Raquel Hontecillas
Aug 12, 2006·Canadian Journal of Physiology and Pharmacology·Paramjit S TappiaHope Weiler
Aug 23, 2008·Nutrition & Metabolism·Yukiko K NakamuraStanley T Omaye
Feb 2, 2012·Journal of Nutritional Science and Vitaminology·Kenta SatoIkuo Ikeda
Mar 5, 2010·The American Journal of Clinical Nutrition·Natalie M RacineDale A Schoeller
Dec 2, 2014·Obesity Research & Clinical Practice·Kazunori Koba, Teruyoshi Yanagita
Apr 24, 2012·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Josep Bassaganya-RieraKim L Isaacs
Jan 7, 2016·Annual Review of Food Science and Technology·Jun Ho KimYeonhwa Park
Nov 26, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A J WandersI A Brouwer
Mar 3, 2007·Prostaglandins, Leukotrienes, and Essential Fatty Acids·André MüllerKlaus Eder
Feb 29, 2008·Molecular Nutrition & Food Research·Jing-Jing LiDong Xie
May 13, 2015·Journal of Food Science·Jun Ho KimYeonhwa Park
May 15, 2015·Nutrition & Metabolism·Sailas BenjaminFriedrich Spener
May 1, 2006·Meat Science·A SchmidG Bee
Aug 23, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A C WatrasD A Schoeller
Oct 13, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C SyvertsenO Gudmundsen
Mar 9, 2006·The American Journal of Clinical Nutrition·Thomas Meinert LarsenArne Astrup
May 11, 2007·The American Journal of Clinical Nutrition·Leah D WhighamDale A Schoeller
Apr 24, 2007·The Journal of Nutrition·Susan E SteckPhilippe Thuillier

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