Safety profile of IBD therapeutics: infectious risks

The Medical Clinics of North America
Waqqas Afif, Edward V Loftus

Abstract

Over the last decade, the medical treatment of inflammatory bowel disease (IBD) has been revolutionized, with increasing use of both immunomodulatory and biologic medications. Corticosteroids have increasingly been shown to increase the risk of serious and opportunistic infections, both independently and in combination with immunomodulator and biologic agents. There are limited data on the infectious risk of immunomodulators. It is unclear if anti-tumor necrosis factor-alpha agents increase overall infectious risk in patients with IBD, but the available literature has demonstrated an increased risk of opportunistic infections, particularly in terms of tuberculosis and histoplasmosis. Combination therapy likely increases the risk of opportunistic infections in patients with IBD but this has not yet been conclusively proved.

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Citations

Jul 23, 2014·Paediatric Drugs·Federica NutiSalvatore Cucchiara
Aug 12, 2014·Gastroenterology Clinics of North America·Uri Kopylov, Waqqas Afif
Jul 24, 2012·Journal of Crohn's & Colitis·Makoto NaganumaMamoru Watanabe
Jul 28, 2015·Expert Review of Clinical Immunology·Federica NutiSilvio Danese
Dec 1, 2015·Expert Opinion on Investigational Drugs·Marc Berns, Daniel W Hommes
Sep 21, 2013·Inflammatory Bowel Diseases·Maneesh DaveEdward V Loftus
May 23, 2013·Inflammatory Bowel Diseases·Miguel E OrdonezJack A Di Palma
Sep 8, 2016·World Journal of Gastrointestinal Pharmacology and Therapeutics·Gianluca AndrisaniLuisa Guidi

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