Safety profile of injectable hydromorphone and diacetylmorphine for long-term severe opioid use disorder

Drug and Alcohol Dependence
Eugenia Oviedo-JoekesMartin T Schechter

Abstract

To review the safety profile of injectable hydromorphone and diacetylmorphine and explore if adverse events (AEs) or serious adverse events (SAEs) were associated with dose and patterns of attendance. This was a non-inferiority randomized double-blind controlled trial (Vancouver, Canada) testing hydromorphone (n=100) and diacetylmorphine (n=102) for the treatment of severe opioid use disorder. Medications were delivered under the supervision of trained Registered Nurses up to three times daily. AEs were described using MedDRA codes. Most common related AEs included immediate post-injection reaction or injection site pruritus reactions, somnolence and opioid overdoses. Adjusted analysis indicated that participants in the hydromorphone group were less likely to have any related AE or SAE compared to the diacetylmorphine group. Related somnolence and opioid overdose events were distributed throughout the six months treatment period. In the diacetylmorphine group, five of the eleven related SAE opioid overdoses (requiring naloxone) occurred in the first 30days since most recent treatment initiation. Analysis of somnolence and opioid overdose (AEs and SAEs) event rates by received dose suggested a non-linear relationship. However, i...Continue Reading

Citations

Feb 13, 2019·Journal of Addiction Medicine·Eugenia Oviedo-JoekesMartin T Schechter
Apr 17, 2020·American Journal of Public Health·Michelle OldingRyan McNeil
May 28, 2020·Research and Theory for Nursing Practice·Marlene Haines, Patrick O'Byrne
Dec 6, 2019·Peptides·Richard J Bodnar
Mar 7, 2021·Substance Abuse Treatment, Prevention, and Policy·Eugenia Oviedo-JoekesKelli Harper
Apr 30, 2021·Early Intervention in Psychiatry·Jean Nicolas WestenbergReinhard M Krausz
May 17, 2021·Research in Nursing & Health·Marlene Haines, Patrick O'Byrne

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