Safety Profiles and Pharmacovigilance Considerations for Recently Patented Anticancer Drugs: Lung Cancer

Recent Patents on Anti-cancer Drug Discovery
Alessandra BearzPaolo Baldo

Abstract

Lung cancer is the most frequent cause of cancer-related death. In the last decades, the introduction of targeted therapies and more recently, of immunotherapy, has led to significant improvements in different outcomes of this malignant neoplasm. The present review provides a balanced overview of most recent targeted therapies and immunotherapies patented for the treatment of lung cancer. An extensive scientific literature and patent databases search were performed to identify peer-reviewed studies containing information on recently patented drugs for the treatment of lung cancer, with a particular focus on their safety data and recently patented combinations. The development of therapies directed to different pathways involved in the tumor angiogenesis, proliferation, and metastasis has transformed the clinical practice of lung malignancies. Several clinical trials have shown an improvement in terms of progression-free survival and overall survival in patients with advanced/metastatic lung cancer. Safety data, extracted from clinical trials and from the WHO global database of adverse drug reactions (VigiAccessTM database), show that recently patented drugs for the treatment of lung cancer are well- tolerated and most of the ad...Continue Reading

References

Nov 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S FujinoA Mori
Feb 13, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·S A Khuder
Mar 14, 2001·The American Journal of Cardiology·J H Stein, P E McBride
Mar 17, 2001·Nature Reviews. Molecular Cell Biology·Y Yarden, M X Sliwkowski
Jan 11, 2002·The New England Journal of Medicine·Joan H SchillerUNKNOWN Eastern Cooperative Oncology Group
Jan 15, 2003·The Journal of School Health·UNKNOWN Office on Smoking and Health, Division of Adolescent and School Health National Center for Chronic Disease Prevention and He
May 12, 2005·Immunology·Laëtitia Maçon-Lemaître, Frédéric Triebel
Oct 20, 2005·Clinical Pharmacokinetics·Helen C SwaislandThierry Duvauchelle
May 7, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lecia V SequistThomas J Lynch
Jul 16, 2008·Advances in Cancer Research·Rachel M A LingerDouglas K Graham
Jan 6, 2011·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Peter StopferThomas Ebner
Mar 8, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Yosuke TogashiMichiaki Mishima
Jun 23, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Taofeek K OwonikokoSuresh S Ramalingam
Aug 29, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·Alexander Eggermont, Olivera Finn
Mar 9, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Helena A YuGregory J Riely
May 23, 2014·JAMA : the Journal of the American Medical Association·Mark G KrisPaul A Bunn
Jul 30, 2014·Journal of Medicinal Chemistry·Weihe ZhangXiaodong Wang
Aug 13, 2014·Cancer·Denise Riedel LewisSusan S Devesa
Apr 22, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Scott N GettingerJulie R Brahmer
Sep 29, 2015·The New England Journal of Medicine·Hossein BorghaeiJulie R Brahmer
Dec 25, 2015·The New England Journal of Medicine·Alice T ShawJeffrey A Engelman
Jun 9, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christophe MassardNeil H Segal
Sep 25, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S NovelloUNKNOWN ESMO Guidelines Committee
Oct 11, 2016·The New England Journal of Medicine·Martin ReckUNKNOWN KEYNOTE-024 Investigators
Dec 24, 2016·British Journal of Clinical Pharmacology·Kathryn BrownEugène Cox
Dec 27, 2016·CPT: Pharmacometrics & Systems Pharmacology·G BajajY Feng
Jan 6, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Mar 16, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tomohide TamuraMakoto Nishio
Apr 1, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paolo G CasaliUNKNOWN European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group, Italian Sarcoma Group, and Au
Aug 19, 2017·Therapeutic Advances in Respiratory Disease·Karim RihawiAndrea Ardizzoni

❮ Previous
Next ❯

Related Concepts

Related Feeds

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Related Papers

Therapeutic Advances in Medical Oncology
Nerea Muñoz-UncetaLuis Paz-Ares
Surgical Oncology Clinics of North America
Emily Z Keung, Jennifer A Wargo
© 2021 Meta ULC. All rights reserved