Safety, tolerability, and immunologic effects of a food allergy herbal formula in food allergic individuals: a randomized, double-blinded, placebo-controlled, dose escalation, phase 1 study.

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
Julie WangXiu-Min Li

Abstract

Food allergy is a common and serious health problem. A new herbal product, called food allergy herbal formula 2 (FAHF-2), has been demonstrated to have a high safety profile and potent long-term efficacy in a murine model of peanut-induced anaphylaxis. To evaluate the safety and tolerability of FAHF-2 in patients with food allergy. In this randomized, double-blinded, placebo-controlled, dose escalation, phase 1 trial, patients received 1 of 3 doses of FAHF-2 or placebo: 2.2 g (4 tablets), 3.3 g (6 tablets), or 6.6 g (12 tablets) 3 times a day for 7 days. Four active and 2 placebo patients were treated at each dose level. Vital signs, physical examination results, laboratory data, pulmonary function test results, and electrocardiogram data were monitored. Immunomodulatory studies were also performed. Nineteen food allergic participants were included in the study. Two patients (1 in the FAHF-2 group and 1 in the placebo group) reported mild gastrointestinal symptoms. One patient withdrew from the study because of an allergic reaction that was unlikely related to the study medication. No significant differences were found in vital signs, physical examination results, laboratory data, pulmonary function test results, and electrocar...Continue Reading

References

Dec 1, 1993·The Journal of Experimental Medicine·H SecristD T Umetsu
Jan 10, 2001·The Journal of Allergy and Clinical Immunology·S A BockH A Sampson
Feb 20, 2003·Journal of Agricultural and Food Chemistry·Scott P DolanStephen G Capar
Mar 17, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·E D Caldas, L L Machado
Aug 28, 2004·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Xiu-Min LiBrian Schofield
Dec 23, 2004·Journal of Agricultural and Food Chemistry·Priyadarshini RamanMuraleedharan G Nair
Jan 8, 2005·The Journal of Allergy and Clinical Immunology·Kamal D SrivastavaXiu-Min Li
Feb 28, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L CosmiE Maggi
Jul 1, 2006·Molecular Nutrition & Food Research·Wesley Burks, Barbara K Ballmer-Weber
Feb 20, 2007·The Journal of Allergy and Clinical Immunology·S Allan BockHugh A Sampson
Apr 26, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Julie Wang, Hugh A Sampson
Aug 8, 2007·The Journal of Allergy and Clinical Immunology·Barbara BohleChristof Ebner

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Citations

Jun 28, 2012·Seminars in Immunopathology·Michele Henson, A Wesley Burks
Apr 16, 2011·Current Allergy and Asthma Reports·Rosalía Ayuso
Nov 18, 2011·Current Allergy and Asthma Reports·Jay A Lieberman, Anna Nowak-Węgrzyn
Nov 22, 2011·Current Allergy and Asthma Reports·Kanao Otsu, David M Fleischer
May 15, 2012·Current Allergy and Asthma Reports·Julie Wang, Xiu-Min Li
Mar 22, 2012·Immunologic Research·Julie Wang, Hugh A Sampson
Sep 4, 2013·Immunotherapy·Aleena SyedKari C Nadeau
Nov 25, 2014·Current Treatment Options in Allergy·Monali Manohar, Kari C Nadeau
May 3, 2014·The Journal of Clinical Investigation·Corinne A Keet, Robert A Wood
Jan 19, 2013·Clinical Reviews in Allergy & Immunology·Yao-Hsu Yang, Bor-Luen Chiang
Oct 27, 2012·Advanced Drug Delivery Reviews·Mike Kulis, A Wesley Burks
Dec 3, 2014·Immunology and Allergy Clinics of North America·Stephanie Albin, Anna Nowak-Węgrzyn
Dec 3, 2014·Expert Review of Clinical Immunology·Giovanni B PajnoGiuseppina Salzano
Aug 21, 2015·Expert Review of Clinical Pharmacology·Aaron K KobernickA Wesley Burks
Jun 5, 2013·Expert Review of Clinical Immunology·Saira Z Sheikh, A Wesley Burks
Aug 27, 2013·Current Opinion in Immunology·Timothy P MoranA Wesley Burks
May 4, 2013·Mayo Clinic Proceedings·Ruchi S GuptaMatthew J Greenhawt
Jul 17, 2012·The Journal of Allergy and Clinical Immunology·Mike KulisA Wesley Burks
May 1, 2012·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Kamal D SrivastavaXiu-Min Li
Jan 17, 2012·Immunology and Allergy Clinics of North America·Julia Ann Wisniewski, Xiu-Min Li
Sep 29, 2011·Current Opinion in Immunology·M Cecilia Berin, Scott Sicherer
Apr 2, 2011·Pediatric Clinics of North America·Anna Nowak-Węgrzyn, Antonella Muraro
Nov 6, 2010·Current Opinion in Immunology·Fred D Finkelman
Mar 1, 2011·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Mark C Stahl, Tonya S Rans
Nov 28, 2012·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P StarklE Jensen-Jarolim
Jun 21, 2011·Immunological Reviews·Stephen R Boden, A Wesley Burks
Nov 3, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Y-H Wang, S P Hogan
Sep 14, 2011·The Mount Sinai Journal of Medicine, New York·Xiu-Min Li
Feb 26, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J Reid-AdamP Heeger
Nov 13, 2013·Allergy·D de SilvaUNKNOWN EAACI Food Allergy and Anaphylaxis Guidelines Group
Feb 12, 2015·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Lauren LisannXiu-Min Li
Jun 6, 2015·The Journal of Allergy and Clinical Immunology·Julie WangXiu-Min Li
Apr 10, 2016·The Journal of Allergy and Clinical Immunology·Robert A Wood
Dec 9, 2014·Human Vaccines & Immunotherapeutics·Sharon Deol, J Andrew Bird
Feb 1, 2011·The Journal of Allergy and Clinical Immunology·Anna Nowak-Węgrzyn, Hugh A Sampson
Mar 8, 2011·The Journal of Allergy and Clinical Immunology·Pooja VarshneyA Wesley Burks
Sep 2, 2014·The Journal of Allergy and Clinical Immunology·Hugh A SampsonRobert Wood
Dec 26, 2012·The Journal of Allergy and Clinical Immunology·Stacie M Jones, A Wesley Burks
Aug 27, 2014·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Nan YangXiu-Min Li
Jan 2, 2013·Allergy, Asthma & Immunology Research·Evelyne Khoriaty, Dale T Umetsu
Aug 23, 2016·Primary Care·Juan Qiu, Kristen Grine
Sep 11, 2016·Allergology International : Official Journal of the Japanese Society of Allergology·Hugh A Sampson
Sep 18, 2016·Allergology International : Official Journal of the Japanese Society of Allergology·Aaron K Kobernick, A Wesley Burks
Jun 27, 2013·Current Opinion in Allergy and Clinical Immunology·Julie Wang
Oct 13, 2016·Expert Opinion on Drug Delivery·Ana Brotons-CantoJuan M Irache

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