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Safety, tolerability, pharmacokinetics and antimalarial activity of the novel Plasmodium phosphatidylinositol 4-kinase inhibitor MMV390048 in healthy volunteers

Antimicrobial Agents and Chemotherapy

Jan 15, 2020

Phumla SinxadiKaren I Barnes

Abstract

MMV390048 is a novel antimalarial compound that inhibits Plasmodium phosphatidylinositol-4-kinase. The safety, tolerability, pharmacokinetic profile, and antimalarial activity of MMV390048 were determined in healthy volunteers in three separate studies. A first-in-human, double-blind, r...read more

Mentioned in this Paper

Syloid 65
Antimalarial Prophylaxis
Tolerability Study
Double-Blind Method
Healthy Volunteers
Pharmacokinetic Study
Adverse Event
Malaria
Malaria, Vivax
Tartaric acid
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Safety, tolerability, pharmacokinetics and antimalarial activity of the novel Plasmodium phosphatidylinositol 4-kinase inhibitor MMV390048 in healthy volunteers

Antimicrobial Agents and Chemotherapy

Jan 15, 2020

Phumla SinxadiKaren I Barnes

PMID: 31932368

DOI: 10.1128/aac.01896-19

Abstract

MMV390048 is a novel antimalarial compound that inhibits Plasmodium phosphatidylinositol-4-kinase. The safety, tolerability, pharmacokinetic profile, and antimalarial activity of MMV390048 were determined in healthy volunteers in three separate studies. A first-in-human, double-blind, r...read more

Mentioned in this Paper

Syloid 65
Antimalarial Prophylaxis
Tolerability Study
Double-Blind Method
Healthy Volunteers
Pharmacokinetic Study
Adverse Event
Malaria
Malaria, Vivax
Tartaric acid

Similar Papers Found In These Feeds

Plasmodium Falciparum

Malaria remains a major cause of morbidity and mortality in the tropics, with the parasite Plasmodium falciparum responsible for the majority of the disease burden. Discover the latest research on Plasmodium falciparum.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

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