Safinamide for the treatment of Parkinson's disease

Expert Opinion on Pharmacotherapy
Ruth Mary deSouza, A H V Schapira

Abstract

The major unmet needs in the medical treatment of Parkinson disease (PD) are reduction of motor side effects from dopaminergic drugs, management of non-motor symptoms and disease modification. Areas covered: Motor fluctuations and OFF periods are a significant determinant of quality of life in PD and reducing their duration and severity can significantly improve motor function. This aim may be partly facilitated by the development of effective adjunctive drugs for dopamine replacement. Safinamide (Xadago), which is a first generation anticonvulsant, has pharmacological properties which are of interest in the context of neurodegenerative diseases, leading to research into its potential as an adjunct to levodopa in PD. Expert opinion: Although its mechanism has not been fully defined, safinamide provides enhanced symptom control of motor function in advanced PD and improves quality of life.

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Citations

Mar 6, 2018·Neurology India·Divya M Radhakrishnan, Vinay Goyal
Jan 23, 2019·Molecular Diversity·Annah N MpitimpitiAnna C U Lourens
Mar 22, 2020·Brain Sciences·Javier PagonabarragaJaime Kulisevsky
Jun 19, 2021·Neurological Research·Edoardo BianchiniFrancesco E Pontieri

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