Safranal of Crocus sativus L. inhibits inducible nitric oxide synthase and attenuates asthma in a mouse model of asthma

Phytotherapy Research : PTR
Syed Imran BukhariManoj K Dhar

Abstract

The present study involves evaluation of antioxidant potential of Crocus sativus and its main constituents, safranal (SFN) and crocin (CRO), in bronchial epithelial cells, followed antiinflammatory potential of the active constituent safranal, in a murine model of asthma. To investigate the antioxidizing potential of Crocus sativus and its main constituents in bronchial epithelial cells, the stress was induced in these cells by a combination of different cytokines that resulted in an increase in nitric oxide production (NO), induced nitric oxide synthase (iNOS) levels, peroxynitrite ion generation, and cytochrome c release. Treatment with saffron and its constituents safranal and crocin resulted in a decrease of NO, iNOS levels, peroxynitrite ion generation, and prevented cytochrome c release. However, safranal significantly reduced oxidative stress in bronchial epithelial cells via iNOS reduction besides preventing apoptosis in these cells. In the murine model of asthma study, antiinflammatory role of safranal was characterized by increased airway hyper-responsiveness, airway cellular infiltration, and epithelial cell injury. Safranal pretreatment to these allergically inflamed mice lead to a significant decrease in airway hyp...Continue Reading

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Citations

Apr 22, 2016·Phytotherapy Research : PTR·Mohammad Hossein Boskabady, Tahereh Farkhondeh
Jun 10, 2016·Phytotherapy Research : PTR·Saeed SamarghandianTahereh Farkhondeh
Aug 9, 2017·Journal of Cellular Biochemistry·Junfeng DuMin Li
Jan 24, 2019·Journal of Cellular Physiology·Mehran PashirzadSeyed Mahdi Hassanian
Dec 29, 2020·Critical Reviews in Food Science and Nutrition·Débora Cerdá-BernadMaría José Frutos
Jun 8, 2021·Frontiers in Immunology·Peeraphong LertnimitphunHongxi Xu
Aug 13, 2021·Environmental Science and Pollution Research International·Mohammad Reza Khazdair, Mohammad Hossein Boskabady
May 4, 2020·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Gopalsamy Rajiv GandhiRicardo Queiroz Gurgel
Aug 27, 2021·Journal of Ethnopharmacology·Bingcong XingQingsong Shao
Sep 18, 2021·Phytotherapy Research : PTR·Neda Roshanravan, Samad Ghaffari
Jan 7, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Syed Imran BukhariM K Dhar

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