SAH gene variants revisited in the European Project On Genes in Hypertension

Journal of Hypertension
Valérie TikhonoffEuropean Project On Genes in Hypertension (EPOGH) investigators

Abstract

Previous studies found significant association of hypertension and hypertension-related phenotypes with genetic variation in SAH (Spontaneously hypertensive rat-clone A-Hypertension-associated). We sought independent confirmation of these findings in the European Project On Genes in Hypertension. We randomly recruited 2603 relatives from 560 families and 31 unrelated subjects from six European populations (mean age 38.8 +/- 15.7 years; 52.1% women). We measured systolic/diastolic blood pressure (mean, 122.4/76.6 mmHg), body mass index (24.9 kg/m2), triceps skinfold (1.7 cm), waist-to-hip ratio (0.83 units), serum total and high-density lipoprotein (HDL) cholesterol (5.14 and 1.33 mmol/l), serum triglycerides (1.95 mmol/l) and blood glucose (4.90 mmol/l). We genotyped the G-1606A and -962del/ins polymorphisms. In all subjects, the allele frequencies were 11.8 and 29.5% for -1606A and -962del, respectively. Lewontin's D' was 0.97 (P < 0.0001). Haplotype frequencies were 58.8% for -1606G plus -962ins, 29.5% for -1606G plus -962del, and 11.7% for -1606A plus -962ins. Both before and after adjustment for covariates, none of the phenotype-genotype associations approached statistical significance. Our study had 80% power to detect on ...Continue Reading

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Citations

Feb 11, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Thomas SehestedtJan A Staessen
Oct 21, 2014·PLoS Computational Biology·Jose A SeoaneTom R Gaunt
Jun 4, 2008·Hypertension·Yu JinJan A Staessen
Mar 10, 2010·Hypertension·Yan LiUNKNOWN International Database on Ambulatory Blood Pressure Monitoring in Relation to Cardiovascular Outcomes Investigators
Mar 10, 2010·Hypertension·Tine W HansenUNKNOWN International Database on Ambulatory Blood Pressure in Relation to Cardiovascular Outcomes Investigators
Nov 17, 2010·Hypertension·Tine W HansenJan A Staessen
Mar 6, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yu JinUNKNOWN European Project on Genes in Hypertension (EPOGH) Investigators

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