Salacia root, a unique Ayurvedic medicine, meets multiple targets in diabetes and obesity

Life Sciences
Yuhao LiJohji Yamahara

Abstract

In many traditional schools of medicine it is claimed that a balanced modulation of several targets can provide a superior therapeutic effect and decrease in side effect profile compared to a single action from a single selective ligand, especially in the treatment of certain chronic and complex diseases, such as diabetes and obesity. Diabetes and obesity have a multi-factorial basis involving both genetic and environmental risk factors. A wide array of medicinal plants and their active constituents play a role in the prevention and treatment of diabetes. Salacia roots have been used in Ayurvedic medicine for diabetes and obesity since antiquity, and have been extensively consumed in Japan, the United States and other countries as a food supplement for the prevention of obesity and diabetes. Recent pharmacological studies have demonstrated that Salacia roots modulate multiple targets: peroxisome proliferator-activated receptor-alpha-mediated lipogenic gene transcription, angiotensin II/angiotensin II type 1 receptor, alpha-glucosidase, aldose reductase and pancreatic lipase. These multi-target actions may mainly contribute to Salacia root-induced improvement of type 2 diabetes and obesity-associated hyperglycemia, dyslipidemia ...Continue Reading

References

Sep 1, 1989·Diabetes Care·C J Bailey, C Day
Dec 1, 1989·Journal of Ethnopharmacology·M D IvorraA Villar
Jan 1, 1974·Journal of the Chemical Society. Perkin Transactions 1·N C TewariS Rangaswami
Jul 1, 1984·Journal of Ethnopharmacology·E H KarunanayakeG Sinnadorai
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·Y T ZhouR H Unger
Jan 9, 2001·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·J C Kaplan, C Junien
May 22, 2001·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·M YoshikawaH Matsuda
Aug 30, 2001·Trends in Genetics : TIG·D E Reich, E S Lander
Sep 18, 2001·Biological & Pharmaceutical Bulletin·T MiuraK Tanigawa
Jan 10, 2002·The Journal of Clinical Investigation·Brian N FinckDaniel P Kelly
Aug 7, 2002·Pharmacology & Therapeutics·Helen VosperColin N A Palmer
May 10, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·B W Wolf, S E Weisbrode
Jul 2, 2003·Cardiovascular Diabetology·Alexander TenenbaumMichael Motro
Oct 1, 2003·Circulation·Muredach P Reilly, Daniel J Rader
Oct 28, 2003·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Masayuki YoshikawaHisashi Matsuda
Apr 7, 2004·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Toshiki MatsuuraMitsuaki Sano
Jul 28, 2004·Cardiovascular Research·Stephan Rosenkranz
Jul 29, 2004·Drug Discovery Today·Richard MorphyZoran Rankovic
Jul 31, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yuying C HwangRavichandran Ramasamy
Nov 3, 2004·Trends in Endocrinology and Metabolism : TEM·László Hunyady, Gábor Turu
Jan 7, 2005·Journal of the American Dietetic Association·Patricia M HeacockBryan W Wolf
Feb 3, 2005·Nature Reviews. Drug Discovery·Curtis T KeithBrent R Stockwell
Aug 12, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M FlammangH Murli
Oct 1, 1993·Planta medica·V VenkateswarluC Veeresham
Mar 16, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Qinglin Yang, Yuhao Li
Jun 15, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M FlammangS M Henwood
Apr 10, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Xianglu RongYuhao Li
Jan 1, 2000·Pharmaceutical Biology·K KrishnakumarP L Vijayammal
Oct 1, 1995·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·R J Marles, N R Farnsworth

❮ Previous
Next ❯

Citations

Jul 24, 2012·Chinese Journal of Integrative Medicine·Neeru VasudevaSurendra Kumar Sharma
Oct 17, 2009·American Journal of Therapeutics·Zafar H Israili
Jan 29, 2013·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Abdolreza GhamarianAzin Nowrouzi
May 13, 2014·Journal of Diabetes Research·Min Kyong SongTom Hsun-Wei Huang
May 20, 2014·Journal of Natural Medicines·Tsutomu ShimadaMasaki Aburada
Aug 27, 2009·Evidence-based Complementary and Alternative Medicine : ECAM·Lan HeYuhao Li
Oct 15, 2013·Canadian Journal of Physiology and Pharmacology·Raja LathaPanchanadham Sachdanandam
May 30, 2009·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·María Dolores GirónJosé M López-Pedrosa
Jun 10, 2009·Evidence-based Complementary and Alternative Medicine : ECAM·Tomoko AkaseMasaki Aburada
Nov 26, 2015·Physiology and Molecular Biology of Plants : an International Journal of Functional Plant Biology·Anjaneyulu MusiniArchana Giri
Jun 3, 2015·Phytotherapy Research : PTR·Sidney J Stohs, Sidhartha Ray
Jul 13, 2011·Fitoterapia·Pathom SomwongAnumart Buakeaw
Aug 18, 2010·Natural Product Reports·Duncan J Wardrop, Samanthi L Waidyarachchi
Aug 14, 2013·Chemistry & Biodiversity·Wei-Guang ShanZha-Jun Zhan
Dec 18, 2018·Endocrine, Metabolic & Immune Disorders Drug Targets·Luciana ScottiMarcus Tullius Scotti
May 4, 2017·Lipids in Health and Disease·Muhammad ImranMuhammad Tauseef Sultan
Dec 7, 2018·Critical Reviews in Food Science and Nutrition·Chao ZhaoHui Cao
Mar 24, 2021·Lasers in Medical Science·Reshu KumariAwadhesh Kumar Rai
Apr 13, 2021·Pharmaceutical Patent Analyst·Hai-Long Zhang, Yiqian Li
Aug 19, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.