Salbutamol delivery from a hydrofluoroalkane pressurized metered-dose inhaler in pediatric ventilator circuits: an in vitro study

Chest
J H WildhaberP N LeSouëf

Abstract

The aim of our study was to determine the in vitro delivery of salbutamol from a pressurized metered-dose inhaler (pMDI) containing hydrofluoroalkane (HFA) propellant through various delivery devices to four models of a pediatric lung. To determine the effect of electrostatic charge, delivery of salbutamol was initially assessed with a multistage liquid impinger (MSLI) through an inline nonchamber device (Baxter MDI Adapter) and a small (Aerochamber MV) and a large (Nebuhaler) inline chamber device. Following this, the delivery was assessed to four lung models appropriate for a child of 70 kg, 50 kg, 15 kg, and 4 kg, with the same three reduced static devices inserted directly into a pediatric ventilator circuit. Reduction of electrostatic charge improved small particle delivery through holding chambers to the MSLI by 12 to 14%. In the ventilator model, the mean delivery was between 1.9% and 5.4% for the nonchamber device, between 14.3% and 27.2% for the small holding chamber, and between 7.2% and 25.7% for the large holding chamber. Delivery was the least efficient in the 4-kg model compared to the 70-kg, 50-kg, and 15-kg models. Salbutamol from an HFA pMDI is delivered efficiently through inline holding chambers with reduced ...Continue Reading

References

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Citations

Jan 15, 2005·Pharmaceutical Research·Sylvia VerbanckWalter Vincken
Jun 19, 2001·International Journal of Pharmaceutics·J C DubusM Dolovich
May 10, 2003·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Vijay JoguparthiPaula Anderson
Mar 21, 2000·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·W H Finlay, P Zuberbuhler
Dec 24, 2011·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Rajiv Dhand
Jun 29, 2005·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Ermindo R Di PaoloJacques Cotting
May 12, 2000·American Journal of Respiratory and Critical Care Medicine·C F Lange, W H Finlay
Apr 1, 2008·Expert Review of Respiratory Medicine·Gene L Colice
Nov 22, 2005·Expert Opinion on Drug Delivery·Hugh D C Smyth
Apr 29, 2008·Clinics in Chest Medicine·Rajiv Dhand, Vamsi P Guntur
Aug 6, 2016·Pharmaceutical Development and Technology·Muhammad H E ElHansyMohamed E A Abdelrahim
Oct 8, 2003·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Gary GrossHarold Guy

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