Salbutamol Worsens the Autonomic Nervous System Dysfunction of Children With Sickle Cell Disease

Frontiers in Physiology
Plamen BokovChristophe Delclaux

Abstract

Sickle cell disease (SCD) patients with asthma have an increased rate of vaso-occlusive crisis (VOC) and acute chest syndrome (ACS) episodes when compared to those without asthma. We hypothesized that either asthma diagnosis or bronchodilator treatment might aggravate SCD via their modulating effect on the autonomic nervous system (ANS). Cross-sectional evaluation of heart rate variability (HRV) during pulmonary function tests, including salbutamol administration, in children with SCD receiving asthma treatment or not when compared to asthmatic children without SCD matched for ethnicity. SCD children with asthma (n = 30, median age of 12.9 years old) were characterized by a reduced FEV1/FVC ratio, an increased bronchodilator response, and a greater incidence of VOC and ACS when compared to SCD children without asthma (n = 30, 12.7 years). Children with asthma without SCD (n = 29, 11.4 years) were characterized by a higher exhaled NO fraction than SCD children. SCD children when compared to non-SCD children showed reduced HRV [total power, low (LF) and high (HF, vagal tone) frequencies], which was further worsened by salbutamol administration in all the groups: reduction in total power and HF with an increase in LF/HF ratio. Aft...Continue Reading

References

Apr 1, 1992·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·C S GarrardD Gordon
Feb 1, 1991·The American Review of Respiratory Disease·P PianosiA Coates
Oct 1, 1994·Journal of the American College of Cardiology·M W AhmedJ J Goldberger
Jun 1, 1997·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·J C Romero MestreP Hernández
Feb 10, 2004·The Journal of Allergy and Clinical Immunology·Bruno MahutJacques de Blic
Aug 2, 2005·The European Respiratory Journal·M R MillerATS/ERS Task Force
Sep 2, 2005·The European Respiratory Journal·J WangerG Viegi
Nov 24, 2005·Chest·Christophe DelclauxFrédéric Galacteros
Nov 29, 2005·Respiratory Physiology & Neurobiology·Bruno MahutChristophe Delclaux
Dec 20, 2005·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Sarah R PearsonW Thomas Boyce
Aug 17, 2006·Journal of Pediatric Hematology/oncology·Jeffrey A GlassbergMichael R DeBaun
Dec 23, 2006·Pediatric Pulmonology·Karl P SylvesterAnne Greenough
Feb 26, 2010·Psychology, Health & Medicine·D E AndersonB G Windham
May 28, 2011·American Journal of Respiratory and Critical Care Medicine·Suvimol SangkatumvongThomas D Coates
Mar 31, 2012·Clinical Hemorheology and Microcirculation·Jennifer M Knight-MaddenMarvin Reid
Feb 23, 2013·Frontiers in Physiology·George E Billman
Dec 29, 2013·Current Opinion in Pediatrics·Jeffrey A GlassbergMichael R DeBaun
Aug 27, 2014·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Adriana Sanches Garcia-AraújoAudrey Borghi-Silva
Jan 1, 2015·Psychosomatic Medicine·LaBarron K HillJulian F Thayer
Jul 17, 2015·Physiological Reports·Patjanaporn ChalachevaMichael C K Khoo
Feb 3, 2016·Chest·Alem Mehari, Elizabeth S Klings
Mar 25, 2016·British Journal of Haematology·Keyne CharlotPhilippe Connes
May 29, 2016·Respiratory Physiology & Neurobiology·Heather EdgellMichael K Stickland
Aug 16, 2016·The Journal of Allergy and Clinical Immunology·Robyn T CohenRobert C Strunk
Dec 7, 2016·Frontiers in Physiology·Vincent PichotFlorian Chouchou
Feb 10, 2017·The European Respiratory Journal·Gerald S ZavorskyAnh Tuan Dinh-Xuan
May 10, 2018·Frontiers in Physiology·Daniela LuciniMassimo Pagani
Mar 15, 2019·Journal of Physiological Anthropology·Junichiro Hayano, Emi Yuda

Related Concepts

Albuterol
Anemia, Sickle Cell
Asthma
Autonomic Nervous System
Cross-Sectional Studies
Diagnosis
Heart Failure
Heart Rate
Sympathetic Nervous System
Pulmonary Function

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Current Opinion in Pediatrics
Shaina M WillenMichael R DeBaun
Current Opinion in Pediatrics
Shaina M WillenMichael R DeBaun
BioMed Research International
Esteban Gomez, Claudia R Morris
© 2021 Meta ULC. All rights reserved