Salicin derivatives from Salix glandulosa and their biological activities

Fitoterapia
Chung Sub KimKang Ro Lee

Abstract

Two new salicin derivatives, saliglandin (1) and 6'-O-(Z)-p-coumaroylsalicin (2), along with fourteen known analogues (3-16) were isolated from the twigs of Salix glandulosa Seemen. The structures of 1-16 were characterized by the use of NMR methods ((1)H and (13)C NMR, (1)H-(1)H COSY, HSQC and HMBC), chemical hydrolysis, and GC/MS. The full NMR data assignment of the known compounds 6, 13, and 14 are reported for the first time. Isolated compounds were evaluated for their nitric oxide (NO) inhibitory efficacy in lipopolysaccharide (LPS)-activated microglial cell (BV-2). Compounds 2, 5, 8-16 significantly inhibited NO production, compound 11 being the most efficacious (IC50 13.57 μM) respectively. Moreover, compound 16 dramatically increased the nerve growth factor (NGF) production (165.24 ± 11.1%) in C6 glioma cells. Taken together, these results revealed that salicin derivatives from Salix glandulosa might have potent effect as anti-neuroinflammatory agents.

References

Sep 24, 2005·Annals of the New York Academy of Sciences·Rinat TabakmanPhilip Lazarovici
Sep 13, 2008·Archives of Pharmacal Research·Seong Ho JeonYong Soo Kwon
Sep 9, 2010·Phytochemistry·Enkhmaa DagvadorjWilhelm Boland
Dec 25, 2010·Journal of Natural Products·Ki Hyun KimKang Ro Lee
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Feb 16, 2013·Bioorganic & Medicinal Chemistry Letters·Chung Sub KimKang Ro Lee
Jan 30, 2014·Journal of the American Academy of Dermatology·Raman K Madan, Jacob Levitt
Aug 8, 2014·Journal of Natural Products·Chung Sub KimKang Ro Lee

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Citations

Oct 30, 2016·Journal of Natural Products·Chung Sub KimKang Ro Lee
Feb 23, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shou-Yuan WuXiao-Ping Song
Jan 9, 2021·Beilstein Journal of Organic Chemistry·Joon Min ChaChung Sub Kim
Mar 2, 2021·Frontiers in Pharmacology·Nora TawfeekAssem M El-Shazly
May 6, 2021·International Journal of Molecular Sciences·Lalita SubediSun-Yeou Kim
Jun 11, 2020·Journal of Natural Products·Kyoung Jin ParkKang Ro Lee
Mar 20, 2020·Journal of Natural Products·Dariya A RomanovaElena V Stepanova

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